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- 저자 : 한병훈(Byung Hoon Hahn) (검색결과 1 건)
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김낙두(Nak Doo Kim),한병훈(Byung Hoon Hahn),이은방(Eun Bang Lee),공재양(Jae Yang Kong),김명혜(Myoung Hae Kim),진창배(Chang Bae Jin) 한국생약학회 1979 생약학회지 Vol.10 No.2
Two pure saponin components, Panax saponin C (protopanaxatriol derivative, ginsenoside Re) and Panax saponin E (protopanaxadiol derivative, ginsenoside Rb_l) were isolated from Panax ginseng root and their acute toxicities in mice and antistress effects in rats were investigated. Average lethal doses (LD_(50)) of ginsenoside Re were 130㎎/㎏ (i.v.), more than 1,000㎎/㎏ (i.p.) and more than 1,500 ㎎/㎏ (s.c.), respectively. Average lethal dose of ginsenoside Rb₁ was 243㎎/㎏ intravenously. Adrenal ascorbic acid and cholesterol contents were significantly decreased when normal rats were exposed to heat (40℃) for 30 min. The reduction of the adrenal ascorbic acid and cholesterol contents in rats was partially prevented when the rats received the ginseng saponins prior to exposure to heat stress and most pronounced effects were observed in rats received ginsenoside Re. However, it was found that administration of ginseng alone, without stress, did not significantly change the ascorbic acid and cholesterol contents in adrenal glands. Eosinophil counts in the blood of the rats were elevated when the rats were exposed to the heat stress, and the elevation of the eosinophil counts were prevented with the ginseng saponins under the stress, but the changes were all insignificant statistically.
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