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피부병변의 정량적 평가를 위한 디지털 컬러 영상 시스템
한병관,정병조,Han, Byung-Kwan,Jung, Byung-Jo 대한의용생체공학회 2007 의공학회지 Vol.28 No.2
In this paper, we introduce a digital cross-polarization and fluorescent color imaging system for quantitative evaluation of skin lesions. We describe the characterization of the imaging systems and the quantitative image analysis methods to show the feasibility for quantitative evaluation of skin lesions. The polarization color image was used to compute erythema and melanin index image which are useful for quantitative evaluation of pigmentation and vascular skin lesions, respectively. The fluorescent color image was used to quantitatively evaluate "sebum" and "vitiligo". In quantitative evaluation of various skin lesions, we confirmed the clinical efficacy of the imaging systems for dermatological applications. Finally, we sure that the imaging systems can be utilized as important assistant tools for the evaluation of skin lesions by providing reproducible quantitative result for widely distributed skin lesions.
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여드름 환자의 얼굴에서 피지량, 여드름 병변수, 모공 형광밀도와의 상관 관계
홍승필 ( Seung Phil Hong ),한병관 ( Byung Kwan Han ),정병조 ( Byung Jo Jung ),배영우 ( Young Woo Bae ),최응호 ( Eung Ho Choi ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Background: Porphyrins produced by Propionibacterium acnes exhibit an orange-red fluorescence spot on the pilosebaceous pore under UVA light. Based on this characteristic, the recently developed photographic technique, ``fluorescence photography``, warrants mention in the context of acne, especially in the assessment of the presence of bacteria and sebum output. Objective: The aim of this study was to assess the relationship between sebum output and acne lesion counts with fluorescent density (% fluorescence area). We discuss the possibility of the use of fluorescence photography as a new tool to evaluate acne and sebum levels. Methods: Total of 39 subjects, 29 males and 10 females, were recruited for this prospective study. To estimate fluorescent density, fluorescent facial images were taken and analyzed with digital fluorescent imaging system and an image analysis program. The sebum output level was measured with a Sebumeter(R). Numbers of acne lesions were counted. Also, sebum output and fluorescent images were compared before and after the use of a facial cleanser containing 1% triclosan. Results: Sebum output level was significantly associated with fluorescent density, but not with the number of acne lesions. However, in the group using triclosan containing cleanser, fluorescent density decreased, while sebum level increased. Therefore, fluorescent density seems to be influenced mainly by the density of P. acnes. Conclusion: Fluorescence density correlates with P. acnes mostly followed by sebum output level. Digital fluorescent imaging system is considered as a useful tool to assess sebum excretion as well as colonization of P. acnes. (Korean J Dermatol 2007;45(9):890∼897)
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