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김서린 ( Seo Rin Kim ),류은경 ( Eun Kyung Rheu ),설영미 ( Young Mi Seol ),차동혁 ( Dong Heuck Cha ),이수진 ( Su Jin Lee ),윤연경 ( Yeun Kyung Yoon ),박순미 ( Soon Mi Park ),김형회 ( Heyung Hoe Kim ),류학선 ( Hak Sun Rheu ),안순철 대한내과학회 2007 대한내과학회지 Vol.73 No.3
Background: The prevalence of HIV drug resistance mutations in drug-naive patients has been shown to differ with geographic origin. The purpose of this study is to assess the prevalence of transmitted antiretroviral drug resistance mutations in drug-naive patients in Korea. Methods: Genotypic resistance was determined by the use of the Viroseq Genotyping System in 42 antiretroviral treatment naive HIV-infected patients between March 2005 and July 2006. Transmitted drug resistance was estimated according to the IAS-USA 2005 definition, taking into account only major mutations in the protease and all mutations in the reverse transcriptase, including revertant mutations at codon 215. Results: The median age of the patients was 42 years and 37 (88%) were male. The median CD4+T cell count was 136/mm3 and the mean plasma RNA level was 4.98 log copies/mL. Among 42 patients studied, 37 (88%) were newly diagnosed patients. None of the patients were recent seroconverters; 38 patients (90%) were infected with subtype B and 4 patients were infected (10%) with the non-B subtype strains (2 patients with CRF01-AE 1 as CRF02-AG; 1 patient with subtype A). Of the 42 subjects tested, we found 2 (4.8%) mutations in NRTI (V118I), but did not find a mutation in NNRTI as well as in the PI region. Conclusions: The prevalence of transmitted antiretroviral drug resistance in drug-naive patients is still low in Korean patients.(Korean J Med 73:243-250, 2007)