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Immunohistological Expression of Caspase-9 on Rat Synovial Membrane under Restraint Stress
진상배 대한안면통증∙구강내과학회 2002 Journal of Oral Medicine and Pain Vol.27 No.3
사회가 발전하고 복잡해지면서 스트레스에 대한 관심은 점점 증가하고 있다. 스트레스란 외부 자극에 대한 신체의 비특이적 반응을 말하는 것이다. 스트레스는 신체의 항상성을 유지하게 하고 자율신경계, 내분비계, 면역계에 영향을 준다. 또한 적응반응, 스트레스 단백질 생성, 가역적 세포자사, 비가역적 세포자사와 같은 세포와 분자수준에서 손상에 대한 반응을 통하여 여러 장기에 영향을 주기도 한다. 이 과정에서 apoptosis가 관여하고 있으며 이에 본인은 스트레스와 측두하악관절활막의 세포자사 과정을 구명하기 위하여 세포자사 과정 중 중요하게 작용하는 단백 분해 효소인 caspase-9의 발현을 관찰하고자 하였다. 웅성 백서 (Sprague-Dawley, 8주) 21마리를 실험 전 기간에 걸쳐 구속 스트레스를 가한 군과 대조군으로 나누고 실험 후 0일, 1일, 3일, 5일, 7일, 10일에 희생시켰으며 실험동물의 측두하악관절 활막을 절취하여 동결절편을 제작하였고 caspase-9에 대하여 ABC 면역조직화학법을 시행하여 관찰하였다. 1. 구속스트레스 군에서 즉일군부터 1일군까지 caspase-9의 발현이 증가하였으며, 3일군부터 점차 감소하기 시작하였다. 2. 구속 스트레스 군에서 활막세포의 수는 0일부터 1일가지 증가하여 여러층으로 나타났으나, 그후 점차 감소하여 7일군에서는 단일층으로 나타났다. 본 연구에서 구속스트레스시 세포의 파괴가 진행되고 caspase-9의 발현이 관찰되었던 바 구속 스트레스에 의한 측두하악관절 활막 세포의 세포자사와 사립체의 변화가 관련이 있다고 사료된다.
Effects of Chronic and Acute Stress on Clusterin Secretion of the Rat Submandibular Gland
진상배,전양현,홍정표,Jin, Sang-Bae,Chun, Yang-Hyun,Hong, Jung-Pyo Korean Academy of Orofacial Pain and Oral Medicine 2006 Journal of Oral Medicine and Pain Vol.31 No.1
The aim of this study is to know how the rat submandibular gland changes under various emotional stress condition, using molecular biological methods. Restraint and chronic unpredictable mild stress (CUMS) experiment is conducted on fifty one 7-week old Sprague-Dawley rats (restraint stress experiment: 21, CUMS: 30). The rats were sacrificed, the submandibular glands were excised immediately at certain time, and examined by the use of immunohistochemistry and western blotting. In CUMS experiment, sucrose preference test, water intake change, weight change were implemented at 1 week interval for the experimental period The results are as follows: 1. The number of clusterin-secreting cells of restraint stress group compared to control group showed significantly decreasing tendency in all experimental groups except for the 1st hour group (p<0.001 in the 9th, 24th, 72nd, 120th, and 168th hour group). 2. The number of clusterin-secreting cells of CUMS group compared to control group showed significantly increasing tendency in the 2nd week group (p<0.01), and significantly decreasing tendency in the 4th and 5th week group (p<0.001). 3. Sucrose preference test in CUMS experiment showed significant difference between the 5th week experimental group and control group (p<0.01). 4. Weight change in CUMS experiment showed significant difference between the 5th week experimental group and control group (p<0.01), but water intake change didn't show significant difference compared to control group. 5. In western blot analysis, clusterin expression was decreased on a gradual basis in due time compared to the control group in the restraint stress group. As for CUMS group (chronic unpredictable mild stress group), it was increased till the 2nd week and decreased till the 5th week after that, which is similar to immunohistochemical analysis result and the decreasing tendency of sucrose preference and weigh changes. Through the test, it was proved that expression of clusterin in saliva glands decreases after receiving either acute or chronic stress, indicating relation with depression caused by chronic stress. Unlike other data, however, apoptotic tendency was hardly found in tissues. Diverse possibilities could be suggested on that: first, the stress was not enough to expedite apoptosis; second, apoptosis-related protein was already being secreted though not detected with microscope; third, clusterin, a major secretion molecule of saliva, decreased with saliva's malfunction due to stress. In the respect, it will be necessary to examine proteins expressed in case of cell death or other heat-shock proteins at the same time, in order to see whether any cellular change or death is caused by decreasing clusterin under high stress, and whether the original state is restored as time goes by under mild stress, through longer-term tests using even higher acute stress.
전방재위치 교합장치를 이용한 비정복성 관절원판변위 환자의 치험례
진상배,홍정표 대한안면통증구강내과학회 1998 Journal of Oral Medicine and Pain Vol.23 No.3
The treatment of anterior disc displacement without reduction patients needs speicific treatment methods different from other Craniomandibular Disorders. Those are manual manipulation, anterior repositioning splint; ARS and step-back. It is well known that the use of Anterior Repositioning Splint is effective on relief of TMJ symptom. But the side effect of long- term ARS wearing, which is irreversible posterior open bite induction, has made many clinicians avoid ARS treatment. This report introduces a clinical case recently proven part- time wearing ARS method for treatment of Disc Displacement without reduction patient' that can reduce side effects with good efficacy. But now clinical statistical studies and basical histophysiological studies are more needed.
진상배(Jin, Sang Bae) 대한치과의사협회 2016 대한치과의사협회지 Vol.54 No.6
Dental care is becoming more available on the NHI(National Health Insurance) in Korea. Especially, complete denture, partial denture, dental scaling, and dental implant has been applied by NHI from 2012 to 2014. Although, the entire nation is not eligible for the benefit now, the more dental coverage of NHI is extended, the more regulaition is tightened. Essential documents for proof of correctness of dental treatment covered by NHI are dental records and the receipt book. Summary of regal regulation about them is as follows 1. Chief complaints of patients, diagnosis, progress, and act of treatment, drugs and materials of treatment, doctor’s sign, date and hour should be placed accurately on dental record 2. Dental clinic should collect patients sharing of the dental cost covered by NHI. 3. Dental clinic should keep the receipt as proof of purchase of dental drugs or materials