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Neurokinin 군 펩티드유사체들의 모르모트 기관 평활근 수축활성
신송엽,하종명,하배진,장태식,강신원,종상 영보 ( Song Yub Shin,Jong Myung Ha,Bae Jin Ha,Tae Sik Jang,Shin Won Kang,Eisuke Munekata ) 생화학분자생물학회 1994 BMB Reports Vol.27 No.5
Neurokinin peptides (Substance P; SP, Neurokinin A; NKA and Neurokinin B; NKB) are a neuropeptide belong to the mammalian tachykinin family. To elucidate the difference in biological properties among neurokinin peptides from chemical structure, the peptide derivatives of neurokinins were synthesized by the solution and solid-phase method and their contractile activities were measured by contraction assay with the smooth muscle of guinea pig trachea (GPT). This study demonstrated that the C-terminal heptapeptide containing two amino acid residues, Asp⁴ and Val^7, is indispensible for contracting activity in GPT. Further, structureactivity studies indicate that the amino acid residues (Ser and Phe) at position 5 from N-terminus play an important role in showing the difference of biological activity between NKA and NKB in GPT assay.