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임상연구 : Desflurane 마취 후 지속 정주된 Remifentanil이 각성 시 기침에 미치는 영향
조혁래 ( Hyeok Rae Cho ),김해규 ( Hae Kyu Kim ),백승훈 ( Seung Hoon Baek ),정규연 ( Kyu Youn Jung ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.6
Background: Coughing during emergence from general anesthesia is a common clinical problem and results in a number of undesirable side effects. Remifentanil stimulate μ-opioid peptide receptor known to be related to antitussive effect. The goal of this study was to evaluate the effect of remifentanil on coughing after general anesthesia with desflurane. Methods: Fifty one ASA physical status I and II patients undergoing elective oral and maxillofacial surgery were randomly assigned to receive either remifentanil with 1 ng/ml effect site concentration or normal saline until extubation. The number and intensity of coughs were monitored during emergence and the recovery time was recorded. Results: The incidence and number of coughing during emergence was significant less frequent in the remifentanil group (P < 0.05). The intensity of coughing was significant milder in the remifentanil group (P < 0.05). There was no significant difference between two groups in the recovery time. Conclusions: Continuous remifentanil infusion with 1 ng/ml effect site concentration during emergence from general anesthesia with desflurane decrease the incidence of coughing without delaying the recovery time. (Korean J Anesthesiol 2008; 55: 670~4)