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흰쥐에서 이부프로펜 리신염의 물리화학적 특성 및 약물동태에 관한 평가
신대환(Dae Hwan Shin),김시현(Si Hyun Kim),박승혁(Seong Hyeok Park),김태성(Tai Sung Kim),한건(Kun Han),정연복(Youn Bok Chung),조한준(Han Jun Jo) 大韓藥學會 2011 약학회지 Vol.55 No.3
Two types of water soluble lysine salts of ibuprofen were prepared and evaluated. Physicochemical properties for ibuprofen-l-lysinate (IBL-l), ibuprofen-dl-lysinate (IBL-dl) and ibuprofen (IB) were studied on melting point, specific ratation, UV spectra and 1H-NMR spectra. There were not differences between IBL-dl and IBL-l in UV spectra and 1H-NMR spectra. The pharmacokinetic parameters of IB were compared to those of its lysine salts (IBL-l and IBL-dl) after i.v. or oral administration at the dose of 50 mg/kg (calculated as IB). Total body clearance (CLt) and area under the plasma concentration-time curve (AUC) were not different between IB group and IBL groups after i.v. administration. On the other hand, IBL-l and IBL-dl produced peak plasma concentrations (Cmax) significantly ealier and higher than IB. Time to reach peak concentration (Tmax) after IBL administration was lower than that after IB administration. There was no difference in AUC across all different groups (IB, IBL-l and IBL-dl) after oral administration. However, absorption rate constant (ka) of IBL-l and IBL-dl were significantly increased than that of IB. These results indicated that the administration of IBL-l and IBL-dl may be advantageous if rapid and reliable onset of pain relief is required.
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항공기 안전운항을 위한 항공등화 보수방식 개선에 관한 연구 : 김포공항을 중심으로
김창은,심종칠,정철화,조한준 한국안전교육학회 1998 한국안전교육학회지 Vol.2 No.2
The role of airport lights system is to carry information as composing the way of lights, and to be designed and be deployed as that way. The crew see this way and know the related position between them and on airstrip, and receive a guide information on flight. Like this, offering analogue information being integrated each airport lights systems like approach lights or runway center line lights is the airport lights system. Because the guide information by the way of light is a direct-reading one by sight, even if it occurs mistakes, it is the things of human senses, such as, the blunder by a illusion or a daze, so you should make efforts to prevent accidents by the cooperation of inter-crews, and continuity with AVIONICS(Aviation Electronics) as a plan. For not only the spiritual safety of pilots, but also the offer of accurate visual information, the safe maintenance and management of airport lights increases the importance in view of the safe airpassage by the pilots nicely connecting two different information. If you maintain the airport lights possessing both reliance and safety through the improvement of repair way of Kimpo International Airport's light, you can previously prevent pilots from spoil a plan accident through the exclusion of human accident cause such as pilot s illusion by airport lights.
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