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박현주(Hyun Joo Park),정인성(In Sung Chung),강성원(Sung Won Kang),조한래(Han Rse Cho),한설혜(Sul Hae Han),한경아(Kyung Ah Han),김주형(Ju Hyung Kim),임양희(Yang Hee Lim),오경식(Kyung Shik Oh) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
Propylthiouracil(PTU) is widely used to treat patients with hyperthyroidism. In rare case, this drug has been found to have toxic effects on the liver. W e experienced a case of PTU in- duced hepatitis in a 45 year old woman treated for Graves' disease with PTU. The biochemi- cal pattern of injury was predominantly hepatocellular with moderately elevated transminase values and histologic findings revealed marked micro and macrovesicular fatty changes and focal necrosis of hepatocytes without any zonal difference. Discontinuation of drug leads to complete recovery in this case. Although overt hepatitis due to PTU is probably a rare compli- cation, there is a potential danger of permanent liver damage. Thus it might be advisable to monitor transaminase levels on regular base in patients receiving PTU.(Korean J Gastroenterol 1994; 26: 369 372)