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Gemcitabine을 사용한 폐암환자에서 발생한 용혈성 요독증후군 1예
박윤정 ( Youn Jung Park ),양근석 ( Keun Suk Yang ),정홍순 ( Hong Soon Jung ),남희철 ( Hee Chul Nam ),정승혜 ( Seung Hye Jung ),김부경 ( Boo Gyoung Kim ),김가영 ( Ka Young Kim ),김정호 ( Jung Ho Kim ),김영옥 ( Young Ok Kim ),윤유선 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.2
Hemolytic uremic syndrome (HUS) is a rare disorder characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS arises from a wide spectrum of conditions, and chemotherapeutic agents have been reported to be associated with HUS, including Mitomycin, Cisplatin, Bleomycin, and Gemcitabine. A 76-year-old man treated with Gemcitabine due to non-small cell lung cancer developed clinical and laboratory findings compatible with HUS. Gemcitabine was ceased and hemodialysis and plasma exchange were utilized and he recovered. A high level of suspicion for HUS is necessary when cancer patients are treated with Gemcitabine, and prompt recognition and treatment are also essential.