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항체의 Cyclic DTPA를 이용한 99mTc 표지시 Polymer 형성과 체내 동태 변화
오옥두(Ok Doo Awh),임상무(Sang Moo Lim),우광선(Kwang Sun Woo),정위섭(Wee Sup Cung) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2
N/A Technetium-99m labeling method using bifunctional chelat.ing agent cyclicDTPA has been evaluated with human polyclonal nonspecific IgG. IgG was conjugated with cyclic DTPA with various molar ratio. Reduction of Tc was done with Na,S,O, with various molar excesa Labeling efficiency and identification of polymer was confirmed with HPLC using TSK4000 SW column. Polymer was purified with 100 cm Sepharose 6LB column. Cultured 1x10' Staphylococcus aureus were injected into rat thigh 24 hours later labeled 1gG was injected, and in vivo distribution was observed 4 and 24 hours thereafter. Reduction of 99mTc was optimal with the 10000-50000 times molar excess of Na2S2O4, Polymer formation increased with increasing mloar excess of cyclic DTPA to IgG. Three step labeling-labeling DTPA conjugated IgG after reduction of 99mTc-rnade more polymer than two two step labeling-simultaneous mixing DTPA conjugated IgG, 99mTc and Na2S2O4,. Tc b]ood clearance and lower uptake in the abscess and other organa. IgG conjugated with 200 times molar excess of cyclic DTPA showed slower blood clearance with 200 times molar excess of cyclic DTPA showed slower blaod clearance than that of 200 times molar excess of cyclic DTPA showed slower blood clearance than that of 20 times molar excess. In the 99mTc labeling of IgG with cyclic DTPA for the immunoscintigraphy, obtimalllabeling condition should be chosen, and effect of the ' Tc labeled IgG polymer should be considered.
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