Commando 手術法에 依한 唾液腺 透明細胞癌腫의 治驗例

Kim Yong Kack(金容珏),Chung Boong Hee(鄭朋喜),Yu Hyeon Seok(劉顯碩) 대한구강악안면외과학회 1988 대한구강악안면외과학회지 Vol.14 No.1

The clear cell carcinoma of salivary gland origin is a recently recognized lesion and has a low grade malignancy. It is found primarily in the major salivary gland, especially the parotid. But it may, however, be found in intraoral sites. This article presents a case of clear cell carcinoma which was confirmed with the aid of electron microscopic findings and treated radically via modified commando operation. The lesion occurred in the right retromolar pad area of a 48-year old man and it invaded underlying bone resulting in radiolucent destruction in mandible. This cleai cell carcinoma was found to be non-mucinous, glycogen-deficient, monomorphic, and originated from minor salivary gland in the intraoral site. To maintain the continuity of the mandible the patient underwent modified commando operation i.e. the composite resection of the tumor mass, marginal mandible and regional lymph nodes by functional neck dissection. After operation, follow up studies revealed good function and no remarkable postoperative complications.

표재 이하선 적출술에 의한 이하선 점액류상피암종의 치험례

김용각(Yong Kack Kim),정붕희(Boong Hee Chung),유현석(Hyeon Seok Yu),곽재근(Jae Keun Kwak) 대한구강악안면외과학회 1989 대한구강악안면외과학회지 Vol.15 No.2

Like most parotid neoplasms, mucoepidermoid tumors are generally considered not to be radiosensitive and the primary approach is surgical. We should be preserve the facial nerve during surgical approach in the parotid gland. This case showed mucoepidermoid tumor in the right parotid gland which occurred in a 53-year-old female. This presented Grade Ⅰ tumor. Therefore, the treatment was performed with superficial lobectomy by four techniques for approaching the facial nerve ; anterior, superior, posterior, and inferior. But transient paresis of the facial nerve occurred in this case, it was recovered completely. And there is no evidence of disease, she is satisfied in function and esthetic aspect.

상악골 악성종양의 외과적 절제후 안면 보철물을 이용한 치험례

김용각(Yong Kack Kim),정붕희(Boong Hee Chung),유현석(Hyeon Seok Yu),곽재근(Jae Kean Kwak) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.1

The current treatment Philosophy for maxillary cancer is an excision of tumor in combination with X-ray radiation. Orbital exenteration is required when invasion of the orbit has occurred from a maxillary cancer. Orbitomaxillary resection results in functional and esthetic problems. There are many limitation to the surgical reconstruction after radiation therapy. And cosmetic results are less satisfactory when surgical reconstruction follows orbitomaxillary resection. This article reports squamous cell carcinoma of maxilla which occurred in a 52-year-old man. PNS CT showed soft mass occupying entire Lt. maxillary antrum, invading the ethmoid air cell and medial aspect of Lt. orbit. This presented the stage Ⅲ(T₃N₀M₀) malignacy. Agter induction chemotherapy, total maxillectomy with orbital exenteration in combination with radiation therapy was performed. Facial prosthesis with prosthetic eye was fabricated with silicone. Esthetic and functional results have been good. And there is no sign of recurrence for the present. But he must be followed for life.

임신백서에 투여된 Isoproterenol이 신생백서 악하선 세포의 증식에 미치는 영향에 관한 면역조직화학적 연구

정붕희,김경욱,이종헌 단국대학교 치의학연구소 1995 단국대치의학연구소논문집 Vol.7 No.1

구강저에 발생한 단독형 신경섬유종

김용각,유현석,곽재근,김규영,정붕희 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Benign neural sheath neoplasms are not common in the maxillofacial region. These lesions can occur as solitary tumors, or they can affect many sites in the form of multiple neurofibromatosis. A solitary neurofibroma is seldom undergo sarcomatous transformation, since solitary neurofibroma is relatively radioresistant and its recurrence rate seems to be low, the treatment of choice is surgical excision. This case showed a solitary neurofibroma in the left side of the floor of mouth which occurred in a 33 - year -old female. The tumor was excised. And there is no evidence of disease. She is satisfied in function and esthetic aspect.

임신백서에 투여된 Isoproterenol이 신생백서 악하선 세포의 증식에 미치는 영향에 관한 면역조직화학적 연구

정붕희,김경욱,이종헌 단국대학교 치의학연구소 1995 논문집 Vol.7 No.1

Isoproterenol, β-adrenergic drug, induce the stimulation of DNA synthesis of parotid and submaxillary gland by single injection and prominant hyperplastic and hypertrophic enlargement by multiple injection. The purpose of this study was to investigate the proliferation, and differentiation of submaxillary gland of new born rat form IPR treated pregnant rats in order to understand the development and cellular proliferation of salivary gland. 150-200 gm, female Sprauge Dawley rats were mated and divided into two groups as control and experimental group. Experimental group were injected at same time on 15, 16, 17 days after preganacy with IPR 16ug/g through intraperitoneum. 5 new born rats were sacrificed at 2, 3, 5, 7, 11, 14, 21, 28 days and 2 submaxillary glands were fixed in Bouin's solution for 8-12 hours. 4um paraffin sections with poly-L-lysin slide were stained with H&E. In order to examine cellular proliferation and differentiation, immunohistochemical staining was done. Anti-PCNA antibody and Anti-EGF antibody as primary antibody, and Rabbit anti- mouse biotinylated IgG and Goat anti-rabbit biotinylated IgG as secon-dary antibody were used with ABC method. DAB as chromogen and balsam mounting were done. PCNA positive cells of submaxillary gland were counted at 3 different sites under the light microscope of 200 power fields. According to the obtained numbers, they were divided into 20 stages and compared with those of control group. EGF positive cells were divided into 5 stages according to their stainability. The results were as follows. 1. Body weight of rat in experimental group markedly decreased after postnatal 21 days than that of control group, while gland weight was 3-3.8 times heavier within postnatal 7 days. 2. Histopathologic features showed mainly proacinar and terminal tubule cells in early stage, while proacinar cells disappeared after postnatal 14 days, and terminal tubule cells markedly decreased but acinar cells prominantly increased. 3. Immunohistochemical features of PCNA showed active proliferation of proacinar cells in postnatal 2 days of experimental group, which were subsided, while acinar cells presented the most active proliferation in postnatal 7 days, and proliferation of terminal tubble cells were to be continued. Proliferation of intercalated and striated duct cells was relatively to be continued. 4. Immunohistochemical features of EGF showed moderate positive mucous cells after postnatal 7 days, and moderate positive terminal tubule cells from postnatal 5 to 14 days. Intercalated duct and striated duct cells showed moderate positivity after postnatal 14 days, and strong on 28 days. From the above mentions, the increased PCNA positivity in postnal 2-7 days strongly suggested transformation of procinar cell into acinar cell. Among the glandular cells, acinar and terminal tubule cells continously showed proliferative activity after postnatal 7 days. EGF positivity of mucous, inter calated duct and striated duct cells were similar to those of control group after postnatal 14 days. It might mean that IPR had little effect on EFG stainability.

구강내 편평상피암에 관한 임상적 연구

정붕희,김재승 단국대학교 치의학연구소 1990 논문집 Vol.2 No.-

A clinical study of selected patients with intraoral squamous cell carcinoma which were managed in the Department of Oral Oncology of Korea Cancer Center Hospital from January 1982 to August 1989 was done. And following results were obtained. 1. Males were involved more than females by intraoral squamous cell carcinoma in a ratio of 4:1, and most of the cases occurred in the 7th and 6th decades (69%). 79% of total patients and 92.5% of males were. 2. The mean duration of symptomatic period was 5.9 months. 3. The common symptoms were swelling (/3%), pain (40%), ulceration (33%), and trismus (23%). 4. In the histologic findings, well differentiation comprised 58.0%. 5. The primary sites were the upper alveolar mucosa (32%), the floor of the mouth (21%), the lower alveolar mucosa (19%), tongue (14%), retromolar trigone (8%), palate (7%) and buccal mucosa (3%). 6. According to TNM system, StageⅠ, Stage Ⅱ, Stage Ⅲ, and Stage Ⅳ comprised 4%, 15%, 32% and 49% respectively. 7. In the management of intraoral squamous cell carcinoma, surgeries were done in the 32 cases, 23 cases of which were managed by radiation therapy or chemotherapy concurrently. And radiation therapy alone was received in 35 cases. 8. Overall 3 and 5-year survival rates without regarding to stage were 27.6% and 21.4%. 9. 3-year survival rate of female patients was 47.2% and that of male patients was 22.6%. 10. 5-year survival rate was 53.9% for "early" cancer (stage Ⅰ and Ⅱ) and 15.6% for "advanced" cancer (stage Ⅲ and Ⅳ). Survival rate of patients in the early stages of cancer appeared to be higher than that of patients with stage Ⅲ and Ⅳ (P<0.005).