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간암에서 FGFR3 mRNA의 과발현과 FGFR3 유전자의 돌연변이 분석
장영균(Young Gyoon Chang),배현진(Hyun Jin Bae),남석우(Suk Woo Nam) 대한약학회 2012 약학회지 Vol.56 No.6
FGFR3 is a member of the fibroblast growth factor receptor family which interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Accumulated evidence suggests that aberrant regulation of FGFR3 and genetic alterations are implicated in the development and progression of various cancers. Despite a high incidence of FGFR3 over-expression, no such investigation has been performed in hepatocellular carcinoma. Thus, we investigated genetic alterations of the FGFR3 gene in 73 cases of hepatocellular carcinoma by single-strand conformational polymorphism (SSCP) and sequencing. One silent mutation (A369A) was found in the extracellular domain of FGFR3, and one genetic alteration in the immunoglobulin-like III domain of FGFR3 appeared to be polymorphism. Taken together, we concluded that over-expression of FGFR3 in hepatocellular carcinoma is not associated with genetic alterations of FGFR3 gene, and we suggest that there could be another underlying mechanism of aberrant FGFR3 expression in hepatocellular carcinoma.
유전체발현 변화 분석을 통한 랫트 간조직에서 다환방향족탄화수소의 위해성을 예측할 수 있는 특이생체지표군의 확립
정광화(Kwang Hwa Jung),노지헌(Ji Heon Noh),은정우(Jung Woo Eun),김정규(Jeong Kyu Kim),배현진(Hyun Jin Bae),사홍건(Hong jian Xie),장영균(Young Gyoon Chang),김민규(Min Gyu Kim),박원상(Won Sang Park),이정용(Jung Young Lee),남석우(Suk Wo 한국환경독성학회 2011 한국독성학회 심포지움 및 학술발표회 Vol.2011 No.10
대단위 발현유전체학 분석을 통한 휘발성 유기화합물에 노출된 랫트 간조직에서의 특징적 분자 신호 해독
김정규(Jeong Kyu Kim),노지헌(Ji Heon Noh),정광화(Kwang Hwa Jung),은정우(Jung Woo Eun),배현진(Hyun Jin Bae),사홍건(Hong Jian Xie),김민규(Min Gyu Kim),장영균(Young Gyoon Chang),박원상(Won Sang Park),이정용(Jung Young Lee),남석우(Suk Wo 한국환경독성학회 2011 한국독성학회 심포지움 및 학술발표회 Vol.2011 No.10