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출혈성 쇼크로 유도된 흰쥐의 위병변에 대한 Allopurinol의 보호 효과에 관한 연구
임종찬 ( Jong Chan Lim ),조현덕 ( Hyun Duk Cho ),김종숙 ( Jong Suk Kim ),이일남 ( Il Nam Lee ),장세경 ( Sei Keung Chang ) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
This study was designed to determine whether oxygen derived free radicals play a role in the pathogenesis of gastric lesions produced by hypotensive ischemia and whether allopurinol, an in-hibitor of xanthine oxidase (the enzyme responsible for the formation of superoxide radicals) has the protective effect on ischemic gastric lesions. To achieve this goal, the changes of antioxidant enzyme activity; xanthine oxidase, superoxide dismutase (a scavenger of superoxide radicals <O-2 >), catalase and peroxidase were measured in control group, in hemorrhagic shock groups and in allopurinol pretreated hemorragic shock groups. Allopurinol pretreated hemorrhagic shock groups were subclassed by dose of administration (25 mg, 50 mg, 75 mg/kg). The resuits were summarized as follows; 1) In hemorrhagic shock group, the activities of total SOD and xanthine oxidase were significantly higher than those in control group (p<0.05). 2) In allopurinol pretreated hemorragic shock groups, the activities of total SOD and xanthine oxidase were lower than those of hemorragic shock group (p<0.05). But there was no linear relation between the increased dose of administration and the inhibition of activities of SOD and xanthine oxidase. 3) The activities of catalase and peroxidase were not significantly different in all groups of this study. 4) The gastric lesions (hemorrhage, edema, erosion) were significantly severe in hemorrhagic shock induced rats irrespective of allopurinol pretreatment compared to control group. And the lesions were more severe in antrum and cardia than the fundus. From the above resu]ts, oxygen derived free radicals may play an important role in the formation of gastric lesions produced by ischemia plus HCI. Allopurinol could have the protective effect on hemorrhagic shock induced gastric lesions by inhibition of xanthine oxidase ivhich is reponsible for the formation of superoxide radicals.