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치료제 Dehydroevodiamine • HCl(DHED) 의 변이원성 연구
성이숙(Yi Sook Sung),정성윤(Sung Yun Jung),정주연(Ju Yeon Jeong),채규영(Gyu Young Chae),진미령(Mi-Reyoung Chin),최봉웅(Bong Woong Choi),장병모(Byeung Mo Chang),김대경(Dae Kyong Kim) 대한약학회 2002 약학회지 Vol.46 No.3
Dehydroevodiamine HC1 (DHED), which is a component separated from Evodia rutaecarpa Bentham, has novel anticholinesterase and antiamnesic activities in th e scopolamine-induced amnesia model. Several studies suggest that DHED might be an effective drug for the Alzheimer's disease and the vascular type of dementia. In order to evaluate the mutagenic potential of DHED, Salmonella typhimurium reversion assay, chromosomal aberration test on Chinese hamster lung cells, in vivo micronucleus assay using mouse bone marrow cells, and comet assay were performed. DHED did not increase the number of revertant in the reverse mutation test using Salmonella typhimurium TA1535, TA1537, TA98, TA100. DHED HC1, at concentration of 5 and 10 jag/m/, increased the number of chromosome aberrated Chinese hamster lung cells with 5 and 10%, respectively. In mouse micronucleus test, no significant increase in the occurrence of micronucleated polychromatic erythrocyte was observed in ICR mice orally administered with DHED. DHED was tested for ability to induce genotoxic effect in L5178Y cells (mouse lymphoma cells) using the single cell gel electrophoresis assay (comet assay). In comet assay, tail moment did not increase in L5178Y cells treated with 10,100, 300 uM DHED .
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치매 치료제 염산 디히드로에보다이아민의 생식 및 발생 독성
성이숙(Yi Sook Sung),정성윤(Sung Yun Jung),서영득(Young Deog Seo),진미령(Mi Reyoung Chin),최봉웅(Bong Woong Choi),장병모(Byeung Mo Chang),김대경(Dae Kyong Kim) 대한약학회 2002 약학회지 Vol.46 No.6
Dehydroevodiamine-HCI (DHED), which is a component separated from Evodia rutaecarpa Bentham, has novel anticholinesterase and antiamnesic activities in a scopolamine- induced amnesia model. Several studies suggest that DHED might be an effective drug for Alzheimer's disease and a vascular type of dementia. DHED was at dose levels of 0, 50, 100 and 200 mg/kg/day administered intraperitoneally to Sprague-Dawley male rats for 60 days before mating and to females from 14 days before mating to 7 days after mating. Effects of the DHED on general symptom and reproductive performance of parent animals and embryonic development were examined. In male parents, whereas no death was observed, reduction in the increase rate of body weight was found at 200 mg/kg. In female parents, both of the mating performance and the fertility of parent animals were decreased at 200 mg/kg, but not significantly. In 200 mg/kg treated group, the fetal death rate was increased but total fetuses showed no changes compared to the control group. There were no malformed F1 fetuses in all groups.
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에멀죤형 액체막에 의한 벤젠 - 싸이클로헥산 혼합물의 분리
장병모,정태수 한국화학공학회 1987 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.25 No.3
비점차가 작은 벤젠-싸이클로헥산 혼합물의 분리에 있어서 에멀죤형의 액체막을 사용하여 혼합물의 조성, 용매/혼합물 체적비, 계면활성제와 글리세롤의 농도 등이 분리계수에 미치는 영향을 실험연구하였다. 조성의 변화에 따라서는 에멀죤과 용매와의 접촉시간이 10분인 경우 분리계수의 평균치가 5.74로서 증류에 의한 분리보다 훨씬 용이하고, 용매/혼합물 체적비는 4일 때 벤젠의 투과는 최대로 되었으며 벤젠-싸이클로헥산 혼합물중 벤젠의 상대용해도비가 크기 때문에 벤젠의 농도가 70㏖% 까지는 농도가 증가할수록 분리계수는 증가한다. 계면활성제의 농도가 1wt% 이하에서는 접촉시간이 증가함에 따라 분리계수가 급격히 증가하나, 1wt% 이상에서는 접촉시간이 증가하여도 분리계수에서는 거의 영향을 미치지 못하므로 계면활성제의 농도가 1wt% 이하에서 가장 효과적이며 막강화제인 글리세롤의 농도는 50wt%에서 가장 효과적이었다. In the separation by emulsion-type liquid membrane of benzene-cyclohexane mixture (the difference between the boiling points of the two components is small), the effects of feed composition, the volume ratio of solvent to feed, surfactant concentration and glycerol concentration on the separation factor have been studied. As the average separation factor of 5.74 for this system at the contact time of 10 minutes for various feed composition, this technique has been found much more effective than the distillation method. Since the relative solubility ratio of benzene in benzene-cyclohexane mixture is greater than that of cyclohexane, the separation factor has been found to increase as the concentration of benzene increases up to 70 ㏖ per cent. It has also been found that the permeation of benzene has reached the maximum value when the volume ratio of solvent to feed is equal to four. The separation has been most effective at the concentration of the surfactant below one weight per cent in which the separation factor increases rapidly with increasing contact time, while the contact time has nearly no effect on the separation factor at the surfactant concentration above one weight per cent. The separation factor has also been effective at the glycerol concentration of 50 weight per cent.
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