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RISS 인기검색어
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- 저자 : 이홍규(Hong Kue Lee) (검색결과 1 건)
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Graves 병에서 항갑상선제 장기치료후 예후인자로서의 TSH 수용체 항체와 TRH 자극시험
임성희(Sung Hee Ihm),조보연(Bo Youn Cho),이홍규(Hong Kue Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),이문호(Mun Ho Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.1
N/A To evaluate the prognostic value of TRH receptor antibodies in Graves' disease and to compare it with TRH stimulation test, TBII activities were measured by radioreceptor assay in 59 patients with Graves' disease during and after 13 months of antithyroid drug therapy and TRH stimulation test was performed in 37 patients in 3 months after drug withdrawal. Within 12 months after the discontinuation of the drugs, 33 patients out of 59 patients (56%) relapsed. Out of 27 patients whose TBII were postive at the time of drug withdrawal 22 patients (8l.5%) relapsed. However in 32 patients whose TBII returned to normal range at the time of durg withdrawal, 21 patients (65.6%) remained in remission for 12 months and 11 patients (34.4%) relapsed. In 14 patients who showed no response to TRH stimulation, 11 patients (78.6%) relapsed. However in 23 patients who showed normal response to TRH stimulation, 19 patients (82.6%) remained in remission and only 4 patients (17.4%) relapsed. In patients who had positive TBII at the time of drug withdrawal and showed no respons to TRH stimulation, 5 patients (83.3%) relapsed, In contrast, 19 patients who had negative TBII at the time of drug withdrawal and normal response to TRH stimulation, 16 patients (84,2%) remained in remission for 12 months. There were no significant differences in predictive values for relapse among TBII positive group, TRH non-responsive group and both abnormal group. These results suggest that 1) positive TBII activities at the end of longterm antithyroid drug treatment is a useful indicator predicting subsequent relapse, and 2) prognostic value of the TBII activities seems to be of the same order as the TRH stimulation test in predicting relapse.
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