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알루미늄 화합물이 흰쥐의 신장대사 및 혈장 Hormone에 미치는 영향
한성희(Sung-Hee Han),김중만(Joong-Man Kim),백승화(Seung-Hwa Baek),이호섭(Ho-Shum Lee),박성수(Seong-Soo Park) 한국식품영양과학회 1996 한국식품영양과학회지 Vol.25 No.1
알루미늄 화합물을 Sprague-Dawley계 수컷 75마리를 5개 그룹, 즉 대조군, 250ppm AlCl₃, 500ppm AlCl₃, 250pppm Al₂(SO₄)₃, 500ppm Al₂(SO₄)₃로 나누어 대사 케이지에 넣어 2주 동안 투여할 경우 체액의 항상성유지, 노폐물의 분비에 이상을 초래할 것으로 생각되어 전해질 농도, sater balance, creatinint, 혈장의 renin 활성도, aldosterone 농도의 변화를 조사하였다. AlCl₃ 투여군은 대조군에 비해 Na^+, creatinine 배설량은 증가하였으나 유리수분의 배설량과 뇨량은 감소하였다. Al₂(SO₄)₃, Na^+, creatinine 배설량은 증가하였으나 Cl^- 배설량은 감소하였다. 혈장 renin 활성도에서는 대조군에 비하여 알루미늄 화합물 투여군은 모두 증가하였으며 AlCl₃군 보다 Al₂(SO₄)₃군이 최고 39.75% 증가되었다. 혈장 aldosterone 농도는 대조군에 비하여 AlCl₃ 250ppm 투여군은 증가하였으나 AlCl₃ 500ppm, Al₂(SO₄)₃ 250, 500ppm 투여군은 가각 16.22%, 17.77%, 41.72%로 감소하였다. This study was performed to investigate the effects of administration of aluminum compound on kidney metabolism and plasma hormone of rats. Seventy five male Sprague-Dawley strains rats were divided into five groups consisting of the control, 250ppm AlCl₃ group, 500ppm AlCl₃ group, 250pppm Al₂(SO₄)₃ group, 500ppm Al₂(SO₄)₃ group and kept on the diet for 2 weeks. The body weight gain was increased by the administration of AlCl₃ but decreased by the administration of Al₂(SO₄)₃ as compared to the control. The urinary excretion of sodium dnd creatinine were increased and free water clearance and urine volume were decreased significantly after AlCl₃ administration group as compared to the control. The water balance, free water clearance, excretion of sodium and creatinine were increased and the excretion of chlorine was decreased after Al₂(SO₄)₃ administration as compared to the control. Plasma renin activity was increased and plasma aldosterone content was significantly decreased after administration of aluminum compounds as compared to the control.