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감염증에서 위점막의 Toll-like Receptor 4 발현
박준용 ( Joon Yong Park ),한동수 ( Dong Soo Han ),김보현 ( Bo Hyun Kim ),강은경 ( Eun Kyung Kang ),이영춘 ( Ying Chun Li ),이항락 ( Hang Lak Lee ),김진배 ( Jin Bae Kim ),손주현 ( Joo Hyun Sohn ),최호순 ( Ho Soon Choi ),강정옥 ( Ju 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
Background/Aims: Toll-like receptors (TLRs) represent a pattern recognition receptors with an ability of specific recognition of pathogens. TLRs appear to respond to pathogens and induce NF- kB activation. TLR2 and 4 seem to be related to the initiation of immune response against gram negative and positive bacteria. We investigated the effect of Helicobacter pylori (H. pylori) infection on the expression of TLRs on the gastric mucosa. Methods: For 35 endoscopic gastric mucosa samples, histologic grading of H. pylori infection and inflammatory cell infiltration were performed. The mRNA expression of TLR2, 3, and 4 was examined by RT-PCR. Immunohistochemistry demonstrated the distribution of TLR2 and 4 in gastric mucosal biopsies. Results: H. pylori positive gastric mucosa expressed higher TLR4/GAPDH ratio than H. pylori negative gastric mucosa (p=0.035), while no significant difference in the expression of TLR2 and 3 was detected (p=0.129, p=0.176). The severity of neutrophil infiltration showed a significant positive correlation with TLR4/GAPDH ratio (p=0.045, r=0.342). Immunohistochemistry using anti-TLR4 and anti-TLR2 antibody revealed the expression of TLR4 in the epithelial cells of H. pylori-infected gastric mucosa. Conclusions: H. pylori infection induces TLR4 expression in the human gastric epithelium, which suggests a certain role of TLR4 in the mucosal inflammatory reaction to H. pylori infection. (Korean J Gastroenterol 2003;41:171-176)