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암컷 랫드의 생식기능에 미치는 반하 (Pinellia ternata) 추출물의 영향
김윤배(Yun-Bae Kim),채희열(Hee-Youl Chai),이기창(Ki-Chang Lee),윤영원(Young Won Yun),김대중(Dae Joong Kim),남상윤(Sang-Yoon Nam),노재섭(Jai Seup Ro),황방연(Bang Yeon Hwang),강현구(Hyun-Gu Kang) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.1
Effects of water extract of Pinellia ternata on vaginal opening, estrous cycle, blood estrogen concentrations and uterine glutathione peroxidase activity were investigated in immature and mature female rats. In pubertal onset assay, immature rats were orally administered with Pinellia ternata extract at doses of 20, 200 or 2,000 ㎎/㎏ for 20 days from day 21 of age, and sacrificed after the final administration for the morphological and enzymatic analyses in reproductive organs. During the administration period, estrous cycle was determined by vaginal cytology from the vaginal opening day. Separately, estrous cycle and daily blood concentrations of estrogen were measured from 11th day during 20-day treatment with Pinellia ternata extract in mature rats of 10 weeks old. In pubertal onset assay, vaginal opening time was somewhat delayed by the administration with Pinellia ternata at all doses used, in contrast to a marked advance in rats treated with 17β-estradiol (10 ㎍/㎏). However, Pinellia ternata increased uterine glutathione peroxidase activity which was also observed in animals treated with 17β-estradiol. Interestingly, Pinellia ternata prolonged the diestrus period in both immature and mature rats. On the contrary, 17β-estradiol arrested the estrous cycle at estrus stage in immature rats, although it prolonged diestrus-proestrus periods in mature animals. Taken together, it is suggested that the water extract of Pinellia ternata might influence the female reproductive function somewhat differently from 17β-estradiol, and that the toxicity and action mechanism of Pinellia ternata following long-term exposure remain to be clarified.