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김경환(Kyung Hwan Kim),김우중(Woo Joong Kim),이명석(Myung Seok Lee),조성태(Sung Tae Cho),김홍열(Hong Yul Kim),윤정이(Jeogn E Yun),권성희(Seong Hee Kwon),안혜경(Hye Kyung Ahn) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.2
Primary biliary cirrhosis(PBC) is a disease of unknown etiology characterized by the destruction of small intrahepatic bile ducts, probably on an immunologic basis. PBC affects mainly middle aged women, and cause cholestasis that may progress to cirrhosis and finally result in the liver failure. We report a case of 39-year-old woman with a initial presentation of general weakness and pruritus for 5 years. Liver biopsy findings were compatible with PBC showing monocyte infiltration, destruction of srnall intrahepatic bile ducts, and periportal fibrosis that were accompanied by negative anti-mitochondrial antibody in repeated tests. (Korean J Gastroenterol 1997; 30:273-279)