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백반증 환자에서 항멜라닌세포 자가항체 활성도의 변화에 관한 연구 - 시험관내 보체매개 멜라닌세포 독성능의 측정 -
박윤기(Yoon Kee Park),한승경(Seung Kyung Hann),송민석(Min Seok Song),윤정구(Jung Ku Yoon),김형일(Hyung Il Kim) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.3
Several observation suggest that the antimelanocyte autoantibodies could play a role in melanocyte destruction. Some experiments indicate that melanocyte antibodies from patients with vitiligo can kill melanocyte in vitro. In these experiments, we demonstrated that vitiligo patient's sera containing antimelanocyte antibodies can lyse cultured human melanocytes by complement activation. Melanocyte cytotoxicity was measured using the ethidium bromide/ acridine orange viability assay. Significant melanocyte cytotoxicity was seen in sera from patients with both active and inactive vitiligo(p<0.01). Melanocyte cytotoxicity measured with complement-mediated cytotoxicity decreased after systemic steroid treatment(p<0.05) ; however melanocyte cytotoxicity showed no significant change with systemic PUVA therapy. (Kor J Dermetol 20(3): 391 3081, 1991)