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박민경(Min Gyeong Park),한상배(Sang-Bae Han),김지연(Jee Youn Kim),박지성(Ji-sung Park),성혜란(Hyeran Sung),윤병규(Byung Kui Yun),송석길(Sukgil Song),이종길(Chong-Kil Lee) 大韓藥學會 2011 약학회지 Vol.55 No.3
Human NK cells, identified 30 years ago based on their ability to spontaneously kill tumor cells, constitute a subset of lymphocytes, which play an important role in the first line of immune defense and the effective function of these cells are enhanced by cytokines. Lung carcinoma has been one of the most commonly diagonosed cancer as well as the leading cause of cancer death in male. Here we provide the evidence that human natural killer cells has inhibitory effects on tumor growth of human lung cancer cell NCI-H460 (non-small cell lung cancer). Enriched NK cell population was obtained by 2 weeks cultivation in interleukin-2(IL-2)-containing medium. The resulting population comprised 26% CD3+ cells, 9% CD3+CD4+ cells, 16% CD3+CD8+ cells, 76% CD56+ cells, 6% CD3+CD56+ cells and 70% CD3-CD56+ cells. Activated NK cells at doese of 2.5, 5, and 10 million cells per mouse inhibited 2%, 12% and 45% of NCI-H460-induced tumor growth in nude mouse xenograft assays, repectively. This result suggests that NK cell-based immunotherapy may be used as an adoptive immunotherapy for lung cancer patients.