http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 유태준(Tae Joon Yoo) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
송정섭(Jeong Sup Song),김관형(Kwan Hyoung Kim),한기돈(Ki Don Han),문화식(Hwa Sik Moon),박성학(Sung Hak Park),유태준(Tae Joon Yoo) 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A Goodpasture`s syndrome has been used as the prototype for autoimmunity to the basement membrane. To induce autoimmune lung disease, we immunized Sprague-Dawley rats with type IU collagen, laminin or CFA (complete Freund`s adjuvant), and boosted twice biweekly. One half of the rats were exposed to 1009 09 for 48 hours or 60 hours and then sacrificed two weeks after the last immunization. The results were as follows: 1) The immunized rats of both groups showed a high antibody titer against each antigen and high lymphocyte proliferative response to concanavalin A and immunizing antigens. 2) Histopathologically; O2 exposed and immunized rats showed neutrophil and plasma rell infiltration into edematous stroma and exudate in alveoli without hemorrhage. There was no IgG depostition in lung tissue by immunofluorescence study. In conclusion, animals immunized with type IV collagen and laminin showed high antibody titer but no deposition of IgG in the alveolar basement membrane suggesting that: a) antibodies did not contact the alveolar basement membrane (ABM) b) antibodies produced are weak antibodies similar to the autologous phase of passive immunization, where the lesions produced are less severe than the heterologous and take longer to develop. Thus the 4H;md 60 hour of increased capillary permeablility may not have allowed enough contact time betwen the ABM and antibody to cause lesions. O2 injury and immune injury to ABM were additive in this rat model. Since there was no 1gCi deposition and thus no evidence for humoral injury, cell mediated immunity contributed to alveolar injury. Thus, in Goodpasture`s syndrome, cell mediated immunity as well as anitobdy and complement mediated injury may contribute to the pathologic changes seen.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
