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      저자 : 유재격 ( Yu Jae Gyeog ) (검색결과 1 건)
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      • KCI등재후보

        고콜레스테롤 식이가 Spontaneously Hypertensive Rat의 체내지질과 항산화성 영양소 상태에 미치는 영향

        유언호 ( Yu Eon Ho ),류왕성 ( Lyu Wang Seong ),김현대 ( Kim Hyeon Dae ),유재격 ( Yu Jae Gyeog ),최영선 ( Choe Yeong Seon ),이희숙 ( Lee Hui Sug ),조성희 ( Jo Seong Hui ) 대한내과학회 1993 대한내과학회지 Vol.44 No.5

        Backgrounds: Hypertension and hypercholesterolemia are two of the most important risk factors for atherosclerosis and cardiovascular morbidity. The mechanism by which hypertension and hypercholesterolemia accelerates atherosclerosis is still uncertain. Methods: To investigate the effect of high cholesterol diet on lipid and antioxidant nutritent status in spontaneously hypertensive rat (SHR), SHRs and Wistar rats were fed diets with or without 2% cholesterol and 0.3% Na-taurocholate for 6 months. Results: SHRs became apparently hypertensive after 2 months of feedings, when their systolic pressure was over 180 mmHg. Heart weight-to-body weight ratios of SHRs were significantly higher than those of Wistar rats. Levels of serum total cholesterol were increased about two-folds and those of liver, ten-folds in both SHRs and Wistar rats by dietary cholesterol. Serum HDL-cholesterol of SHRs were significantly lower than those of Wistar rats and HDL·/total cholesterol. Serum TG levels were not changed, but liver levels increased by dietary cholesterol and lower in SHRs. Serum TBARS levels were higher in SHRs, but little changed by dietary cholesterol. Liver levels appeared to be higher in SHRs and cholesterol groups. Serum and liver vitamin E levels were lower in SHR. Serum vitamin A levels were little changed, but liver contents were somewhat decreased in SHRs and remarkably reduced by dietary cholesterol. Conclusions: It is concluded that hypertension and hypercholesterolemia, individually, result in accumulation of lipid peroxide as well as consumption of body tocopherol and retinol, which can be further augmented by coexistence of two abnormal conditions.

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