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이종 췌도 이식을 위한 Ba²+-알진산 미세피막화 췌도 형성
박헌석 ( Heon Seok Park ),함동식 ( Dong Sik Ham ),유영혜 ( Young Hye You ),신주영 ( Ju Young Shin ),김지원 ( Ji Won Kim ),조재형 ( Jae Hyoung Jo ),김온유 ( On You Kim ),강길선 ( Gil Son Khang ),윤건호 ( Kun Ho Yoon ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.5
Islet transplantation is one of the promising treatment strategies for the cure of diabetes. However, the hurdles such as shortage of human tissue, immune rejection and recurrence of autoimmunity should be overcome for successful islet transplantation. Xeno-transplantation can be a solution to shortage of human sources. Immune isolation by microencapsulation of islet with alginate polymer could escape the immune injuries. Microencapsulated xenoislet transplantation is a one of the ideal strategies to cure the diabetes. Here, we introduce microencapsulation of islets for successful xenogenic islet transplantation. We achieved optimization of encapsulating condition. First, we demonstrated viability and insulin secreting capacity of encapsulated islets in vitro. We confirmed their ability of maintaining normoglycemia and escaping immune rejection after rat or porcine islet transplantation to diabetic mouse models.