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풍선도자에 의한 흰쥐의 경동맥 손상 후 phospholipase C-γ1 발현의 변화
임성훈(Seong Hoon Lim),허영선(Young Sun Heo),김학진(Hak Jin Kim),이왕수(Wang Soo Lee),안지현(Ji Hyun Ahn),송영빈(Young Bien Song),김상욱(Sang Wook Kim),김태호(Tae Ho Kim),김치정(Chee Jeong Kim),류왕성(Wang Seong Ryu),유언호(Un Ho Ryo 대한내과학회 2001 대한내과학회지 Vol.60 No.3
Background : While inositol phospholipid-specific phospholipase C (PLC) plays a central role in signal transduction pathways, little is known about its role in the vascular response to injury. Recent studies have shown that phospholipase C-γ1 (PLC-γ1) is required for PDGF-induced DNA synthesis and angiotensin II signaling. This study was undertaken to determine the potential involvement of PLC-γ1 in the in vivo response to vascular injury. Methods : Vascular injury was achieved in the left common carotid artery of six-month-old male Wistar rats. The expression of PLC-γ1 was evaluated at serial time points by immunohistochemistry and Western blot analysis following balloon de-endothelialization of the rat carotid artery. Results : In the denuded carotid artery at 1 week, the neointima became thicker in a symmetrical manner with respect to the long axis. A strong expression of PLC-γ1 at one week after injury was seen primarily in the thin layers of neointima. This increased immunoreactivity of PLC-γ1 persisted at 2-3 weeks after injury, coinciding with the time when neointima gains of its mass. At 4 weeks after injury, staining intensity slightly declined but levels remained elevated. As determined by Western blot analysis, the amount of PLC-γ1 was about 3-fold higher at 3 weeks after injury compared to uninjured vessels (p<0.01). Conclusion : These results suggest that the amplification of traffic within signal transduction pathways involving PLC-γ1 occurs and may play a significant role in neointima formation following arterial injury.(Korean J Med 60:234-241, 2001)