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- 저자 : 유병훈 ( Byung Hoon You ) (검색결과 1 건)
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임상연구 : Propofol을 이용한 마취 유도 후 근이완제 투여 없는 기관내 삽관 시의 Remifentanil의 적정 용량
김기석 ( Ki Seok Kim ),김범진 ( Bum Jin Kim ),이상석 ( Sang Seok Lee ),유병훈 ( Byung Hoon You ),우승훈 ( Seung Hoon Woo ),홍기혁 ( Ki Hyuk Hong ),이윤석 ( Yoon Suk Lee ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.4
Background: Many studies have shown that tracheal intubation could be facilitated after induction with propofol and opioids without muscle relaxants. Remifentanil, which has a rapid onset and ultra-short duration of action, is a useful estrase-metabolized opioid (EMO) for tracheal intubation. This study was designed to evaluate the adequate induction dose of remifentanil with propofol 1.5 mg/kg for tracheal intubation without muscle relaxants. Methods: We have assessed intubating conditions in five groups of 57 female patients, ASA PS I or II. Each group was administerd intravenous propofol 1.5 mg/kg with remifentanil 1.0μg/kg, 2.0μg/kg, 3.0μg/kg, 4.0μg/kg and 5.0μg/kg, respectively. Intubation was attempted, and the intubating condition was scored by the degrees of relaxation of jaw (0-2), position of vocal cords (0-2) and the patient response (0-2). Mean arterial pressure (MAP) and heart rate (HR) were observed at each group. Results: The relationship between the concentration of remifentanil and the possibility of endotracheal intubation was as following: Probit (P) = - 1.38 (S.E.: 0.58) + 0.087 (S.E.: 0.23) × DRemi. The ED50 of remifentanil for endotracheal intubation without muscle relaxants was 2.12 (95% confidence interval: 1.42-2.62) μg/kg and the ED95 was 4.01 (95% confidence interval: 3.31-5.92) μg/kg. Conclusions: We concluded that adequate dose of remifentanil which make possible to endotracheal intubation without muscle relaxants after induction of general anesthesia with 1.5 mg/kg of propofol is 4.01μg/kg in 95% of female patients and 2.12μg/kg in 50% of female patients. (Korean J Anesthesiol 2006; 51: 405~10)
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