임상 : 폐암에서 전이된 단일 병소 뇌종양 환자에서의 감마나이프 방사선수술

우현진 ( Hyun Jin Woo ),박성현 ( Seong Hyun Park ),황성규 ( Sung Kyoo Hwang ) 대한뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.1

Objective:Stereotactic radiosurgery has become a valued management choice for patients with brain metastases. This study was performed to assess the efficacy of GKS(Gamma knife radiosurgery) in patients with solitary brain metastasis. Methods:From May 2005 to Dec 2007, fourteen patients(8 men and 6 women) with solitary cerebral metastatic lesion underwent GKS. The mean age was 61 years(49-74). All patients had Karnofsky performance status(KPS) score of 70 or better. The maximum diameter of the single brain metastasis was less than 3 cm. Overall survival was retrospectively analyzed by using Kaplan Meier method and variables associated with survival were evaluated by univariate analysis. Results:The mean volume of solitary brain metastatic lesions was 6.1 cc(0.5-24.5). The median marginal dose was 20 Gy(10-23). Median follow-up period was 40 weeks. Overall median survival was 32 weeks(4-88) from GKS. Local control rate was possible for 77% of the lesions. At the last follow-up, 12 patients(86%) were alive and 2 patients(14%) died from systemic causes. Age(<65 years, p=0.003) and high KPS score(>80, p=0.024) were favorable prognostic factors in univariate analysis. Conclusion:GKS has significantly reduced the mortality from brain metastasis by effectively accomplishing local tumor control in patients with solitary brain metastasis from lung cancer.

나노피브릴화 셀룰로오스의 제조 및 PVA 복합필름의 성질에 미치는 효과

우현진(Hyun Jin Woo),김준호(Joon Ho Kim) 한국고분자학회 2018 폴리머 Vol.42 No.1

Eucalyptus 크라프트 펄프를 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)로 처리하여 셀룰로오스를 부분 산화시킨 후, 초미세분쇄기, 고압 균질화기 등의 기계적 처리로 나노피브릴화 셀룰로오스(NFC)를 제조하였다. NFC의 형태, 카복시기 함량, 유변학적 특성 등을 측정하였으며, NFC가 소량 혼합된 PVA 복합필름을 제조하여 광학적 특성과 기계적 성질 등을 평가하였다. 나노피브릴화 셀룰로오스의 섬유직경은 기계적 처리 횟수가 증가함에 따라 감소하였다. PVA/NFC 복합필름의 기계적 특성은 NFC 함량 0.05 wt%에서 가장 우수하였으며, 극소량의 NFC의 첨가로도 필름의 기계적 특성은 상당한 수준으로 향상되었으며, NFC 첨가에도 불구하고 PVA 필름의 광투과도의 손실은 크지 않았다. The fibrillation of cellulose from eucalyptus kraft pulp was obtained by oxidation treatment with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) as chemical pretreatment at pH 10. The chemically-treated cellulose was followed by mechanical treatments such as ultrafine grinding or high-pressure homogenization treatments to yield nanofibrillated cellulose (NFC). The morphology, carboxyl group content, and rheological properties of the prepared NFC were measured. Poly(vinyl alcohol) (PVA) composite films containing small amount of NFC were prepared and the optical and mechanical properties of the films were evaluated. The fiber thickness of NFC decreased with increasing pass number of mechanical treatments. The mechanical properties of the PVA/NFC composite films were the best at 0.05 wt% of NFC content. The film showed small decrease in the optical transmittance with increase in the added amount of NFC.

한국 중학생의 영어학습동기와 듣기전략 사용이 영어듣기 능숙도에 미치는 영향 : 자기결정성 이론에 기초하여

우현진 이화여자대학교 교육대학원 2007 이화교육논총 Vol.17 No.-

The seventh national curriculum of South Korea places great emphasis on promoting learner autonomy and self-directed learning. To do so, it is necessary to have a comprehensive understanding of learners' motivation and strategy use. Recognizing the importance of the student role in foreign language learning, much effort has been expended in the past on the empirical examination of the effects of English learning motivation and strategy use on English achievement. However, previous studies have not provided a systematic and comprehensive understanding of the causal relationships of those variables within a single framework. Moreover, there has been a lack of attention to the individual language skills in most studies of English learners' motivation and strategy use even though they are known to be skill and task-specific, In addition, less attention has been paid to self-determination theory, which constitutes a useful framework for studying motivation in EFL context, due to the dominance of Gardner's (1985) socio-educational model in the field of language learning motivation over the past thirty years. Therefore, the present study examines the applicability of the self-determination framework to Korean adolescent EFL learners, and investigates the effects of the different types of motivations based on the self-determination theory and the cognitive/metacognitive listening strategy use on Korean middle school students English listening proficiency through analyses of the structural equation model concerning the causal relationships of the latent variables, In order to check their reliability and validity/ a preliminary motivation questionnaire and a preliminary listening strategy use questionnaire were administered to 410 and 107 middle school students in Seoul, respectively. A total number of 202 middle school second graders in Seoul participated in the main study. The self-report questionnaires from the preliminary study were used to assess five different types of students' motivations (amotivation, extrinsic regulation, introjected regulation, identified regulation, and intrinsic regulation) and the use of two different types of listening strategies (cognitive and metacognitive). The main results are as follows. First, factor analyses revealed the underlying five-factor structure of the self-determination theory, extracting five factors that represent the hypothesized motivational constructs. The canonical correlation matrix, overall, confirmed the existence of five subtypes of motivation on a self-determination continuum, showing a simplex pattern; that is, there are strong positive correlations between adjacent concepts and less positive or perhaps even negative correlations between concepts further apart. These results suggest that the Korean adolescents' English learning motivation can be validly assessed using the intrinsic and extrinsic subtypes of self-determination theory. This will provide a useful theoretical framework for future studies of English learning motivation in Korea. Secondly, the descriptive analysis revealed that identified regulation was the strongest among the five subtypes of motivation followed by intrinsic, introjected, and extrinsic regulation, and amotivation was the weakest, which suggests that Korean middle school English learners have internalized the extrinsically oriented behaviors and values to a significant extent. Another finding was that the Korean students used more cognitive strategies than metacognitive strategies, and it reflects the fact that Korean students often resort to various inferencing and elaboration strategies to cope with the difficulties in listening comprehension. Thirdly, the causal analysis of the structural equation model on the relationships among English learning motivation, listening strategy use, and listening proficiency revealed several findings as follows. First, the cognitive strategy use was found to be the only variable with a direct positive effect on English listening proficiency and had the most positive total effect of .363 among all independent latent variables included in the model. Secondly, the model indicated that amotivation, as expected, had a significant direct negative effect on the proficiency and metacognitive strategy use. Thirdly, metacognitive strategy use and intrinsic regulation were found to have significant indirect positive effects on the proficiency, mediated by cognitive strategy use. Lastly, the model also indicated that the more internalized types of motivation tend to have more positive effects on the listening proficiency. It suggests the importance of the internalization process of extrinsically oriented values in language learning. The results of this study are expected to be utilized as a basic framework for developing a more learner centered and self-directed English listening program by providing a comprehensive understanding of the causal relationships among Korean adolescents' English learning motivations, listening strategy use, and English proficiency.