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골수염 치료제인 항생제비드 ( CJ-40003 ) 유효성분의 일반약리작용
김영훈(Young Hoon Kim),최재묵(Jae Mook Choi),온윤성(Yoon Seong On),연규정(Kyu Jeong Yeon),이윤하(Youn Ha Lee),김제학(Je Hak Kim),이영수(Young Soo Lee) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.1
A new antibiotic bead, CJ-40003 is a combination of three antibiotics, tobramycin, vancomycin and cefazolin embedded in bone cement, for the treatment of osteomyelitis. To evaluate the general pharmacological properties of CJ-40003, the effects of its active ingredients were investigated in mice, rats, dogs and isolated guinea pig ileum. The combination of three antibiotics (CA) did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electrolytes excretion when administered intravenously at the doses of 0.3, 1 and 3 mg/kg, respectively, into experimental animals. The CA had no effect on the contractile response of the isolated guinea pig ileum to various spasmogen at concentrations of 1, 3 and 10 ㎍/ml, respectively. In conclusion, the active ingredients of CJ-40003 showed no pharmacological effect in these studies.