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인슐린 비의존형 당뇨병환자들에서의 Euglobulin 섬유소 용해능
조용욱(Y . W . Cho),오도연(D . Y . Oh),김선주(S . J . Kim),홍세용(S . Y . Hong) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A Defective fibrinolysis, which has been associated with an increased risk of thromboembolic disease, may be relevant to the vascular complications of diabetes. The euglobulin lysis area was measured in 56 NIDDM patients and 116 healthy controls before and after a venous occlusion, and the following results were obtained: 1) Compared to the control groups, there were significantly lower basal and stimulated euglobulin lysis areas in diabetics. The serum fibrinogen Are you malang a garacl stctement lee which wrtrasts with the net og the sentane, on it gyyoset to be tendel, as pant of you ieult? tends be lower in diabetes, but there was no statistical significance. 2) No relation of fibrinolytic activity to age, duration of diabetes, sugar, serum lipid, or obesity was found. 3) Both basal and stimulated fibrinolytic activity were significantly lower in diabeics who developed retinopathy than in diabetics who were fuee of retinopathy, In diabetics, serum fibrinolytic activity is lower than in healthy controls, a finding which could play a role in the development of diabetic retinopathy.
Lumbricus Rubellus 가 인체의 섬유소 용해력에 미치는 영향
홍세용(S . Y . Hong),양동호(D . H . Yang),오도연(D . Y . Oh),박선양(S . Y . Park) 대한내과학회 1991 대한내과학회지 Vol.40 No.1
N/A To evaluate the lumbrikinase effect on plasmin (ogen) related physiologic fibrinolytic activity, we measured euglobulin fibrinolytic activity, t-PA activity and t-PA antigen during lumbrikinase therapy and the results were compared with the data of control day of before and after lumbrikinase ingestion. Serial dilution of lumbrikinase showed the fibrinolytic activity on fibrin plate by dose dependent pattern between 375㎍/ml and 1㎍/ml concentration. In regard to the fibrinolytic area, 300㎍ of lunbrikinase equivalent to 25 unit of t-PA and 75㎍ of lumbrikinase equivalent to 5 unit of t-PA. Euglobulin fibrinolytic activity increased in all cases by two or three days after lumbrikinase ingestion but decreased to basal level 36 hours after discontinuation of lunbrikinase. The lumbrikinase added to plasma did not influence to the euglobulin fibrinolytic activity. t-PA ag was increased in 5 out of 6 cases and t-PA activity was increased all of the cases after lumbrikinase ingestion. There was direct correlation between euglobulin fibrinolytic activity and t-PA activity. This finding suggest that the increased fibrinolytic activity of euglobulin after lumbrikinase ingestion is due to increased t-PA rather than direct effect of lumbrikinase itself.