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CFA로 유도한 관절염에서 선혈(選穴) 따른 전침(電鍼)의 진통효과 차이
양범식 ( Bum Sik Yang ),구성태 ( Sung Tae Koo ),김경식 ( Kyoung Sik Kim ),손인철 ( In Cheul Sohn ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.1
Objective: In the present study, the effect of electroacupuncture (EA) applied to several acupoints and non-acupoint in CFA-induced knee arthritis was examined. Methods: A common source of persistent pain in humans is arthritis. Arthritis was induced by injection of CFA 125 ㎕ into knee joint cavity under enflurane anesthesia. The rat subsequently showed swelling of the ankle and a reduced stepping force of the affected limb for the next several days. The reduced stepping force of the limb was presumably due to a painful knee. EA was applied to either of LR2, LI4, or non-acupoint on the contralateral forelimb for 30 min under gaseous anesthesia. After the termination of EA, behavioral tests measuring stepping force were periodically conducted during the next 4 h. Results: EA applied to LR2 point produced a significant improvement of stepping force of the affected foot lasting for at least 2 h. However, neigher LI4 point nor non-point produced any significant increase of weight bearing force. The improvement of stepping pressure was interpreted as an analgesic effect. The analgesic effect was specific to the acupuncture point since the analgesic effect on CFA-induced knee arthritic pain model could not be mimicked by EA applied to a point, LI4 or non-acupoint. In addition, both NO production and iNOS protein expression increased by arthritis were suppressed by EA applied to LR2 point. Conclusion: These data suggest that EA produces a potent analgesic effect in the rat model of CFA-induced knee arthritis. This analgesic effect is produced by applying EA to an acupoint at opposite side from the painful area in a stimulus point-specific way.
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흰쥐의 족과(足跨) 염좌(捻挫) 통증(痛症)에 대한 양노(養老)(SI6) 전침(電鍼)의 진통(鎭痛) 기전에 대한 연구(硏究)
양범식 ( Bum Sik Yang ),김재효 ( Jae Hyo Kim ),장재훈 ( Jae Hun Jang ),안성훈 ( Sung Hun Ahn ),김경식 ( Kyoung Sik Kim ),손인철 ( In Chul Sohn ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.3
Objectives: The purpose of the present study is to determine the effective analgesic parameters of manual acupuncture (MA) and/or electroacupuncture (EA), thus how MA & EA of specific acupoint works after acute ankle sprain in rats. Thus, one series of experiments was designed to analyze the analgesic effects of acupuncture in either the normal or sprained rat, by comparing the behavioral features before and after MA or EA at several acupoints. Methods: Ankle sprain was induced manually by hyper-extension of Ligaments of the right ankle in rat. Either MA or EA was applied to the LI4, TE17, 足三里and SI-6 acupoints at an intensity of 2 mA (1 ms pulse duration) with a frequency of 10 Hz for 30 minutes. Results: Behaviorally, manual acupuncture or electroacupuncture produced potent analgesic effects on acute ankle sprained animals as measured by weight bearing capacity of the affected Limb. Furthermore, antinociceptive effect of EA was suppressed by alpha adrenoceptor antagonist phentolamine (5 mg/kg, i.p.) but not by opioid antagonist naltrexone (10 mg/kg, i.p.). Conclusions: It is suggested that acupuncture-induced antinociception may involve the descending inhibition of α2-adrenoceptor.
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