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플라즈몬 나노 입자의 광학적 특성을 활용한 세포 노화 측정에 대한 수치적 연구
김윤(Yun Kim),안현지(Hyun-Ji An),최인희(Inhee Choi),송지환(Jihwan Song) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.8
As the cells are senescent, the topology of the chromatin in the cell changes. Histones, which are located at the chromatin, also change their distribution according to the topological change of chromatin. The topology of chromatin can be analyzed by attaching detectable substances to the histones. Conventional methods, such as using fluorescent dyes, have disadvantages in the analysis of the histone distribution including the arrangements and distances because they only can provide blurred images. Plasmonic particles (e.g., Au and Ag) can be adopted to overcome these drawbacks. They show distinct optical characteristics when their arrangements and distances are varied. Herein, we studied the distinct optical properties according to the varying inter-particle distance, arrangements, and number through computational simulation. In addition, the distributions of the histones were predicted in comparison with the experimental results. We believe this method which can provide more clear information including inter-particle distance and their arrangements will help monitor the progress of the diseases or senescence.