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현진해(Jin Hai Hyun),류호상(Ho Sang Ryu),김창덕(Chang Duck Kim),심경보(Kyung Bo Shin) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
N/A The purpose of the present syudy is to determine whether the serum concentration can represent as a tumor marker of gastric cancer, the extent of gastric cancer, and can reflect the liver metastasis of gastric cancer. The fasting serum copper concentration was measured in 8 healthy adult as normal controls, 26 gastric cancer and 55 patients with other cancer. The results were as follow: 1) The serum copper concentration was 120.25+25.12 mcg/dl in normal controls and 153+39.56 mcg/dl in patient with gastric cancer. 2) The serum copper concentrations of advanced gastric cancer patients (with liver metastasis) was markedly elevated than normal control, but not in patients with stageIIl gastric cancer. 3) The serum copper concentrations was more than 130 mcg/dl in most patients of stage llI gastric cancer and more than 150 mcg/dl in most patients of stage III gastric cancer and more than 150 mc/dl in stage IV gastric cancer (liver metastasis) patients. 4) The serum copper concentrations of lung and bile ductular cancer were more elevated than that of other malignancies. This results that serum copper concentration seems to be a simple and reliable tumor marker for the extent as well as liver metastasis of gastric cancer.