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順氣除濕方이 高脂肪食餌로 유발된 肥滿 白鼠에 미치는 영향
이우열(Lee Wooyeol),신현규(Shin Hyunkyoo) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.1
Objective : In order to investigate the effects of Soongijeseub-bang(here in after referred to SJB) on the obese gene and obese inhibitory, C57BL/6 mice were induced by high fat diet. Methods : C57BL/6 mice were divided into three groups(normal, high fat diet with control, high fat diet with SJB extract) and fed for 15 weeks. And measured body weight change, the weight change of the adipocytes in body, the levels of ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, NEFA(non-esterified fat acid), glucose in serum and the expression of β3AR, leptin, and TNF-α gene in primary adipocytes and adipocytes tissue. Results : The following results were obtained in this study. 1. SJB 500 ㎎/㎏ extract group showed significant decrease in final weight. 2. SJB 500 ㎎/㎏ extract group showed significant decrease in the amount of adipocyte in weight. 3. All experimental group showed significant decrease in ALT and AST levels. 4. All experimetal group did not show significant decrease in glucose and creatinine levels. 5. All experimental group showed significant decrease in total cholesterol, LDL-cholesterol, triglyceride and NEFA levels. HDL-cholesterol were increase significantly in SJB 500 ㎎/㎏ extract group. 6. SJB 500 ㎎/㎏ extract group showed significant decrease in leptin levels. 7. All experimental group showed significantly increased expressions of β3AR in primary adipose cell and 3T3-L1 cell, and those of leptin in primary adipose cell and 3T3-L1 cell were decreased significantly. SJB 100 ㎕/㎖ extract group showed significant decrease in the expression of TNF- α. 8. SJB 500 ㎎/㎏ extract group showed decrease in the size of adipocyte in adipocytes tissue. 9. All experimental group showed significant decrease in adipose vacuoles in liver tissue.
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이남헌(Lee Namhun),하혜경(Ha Hyekyung),이호영(Lee Hoyoung),정다영(Jung Dayoung),최지윤(Choi Jiyoon),최영재(Choi Youngjae),정승일(Jeong Seungil),신현규(Shin Hyunkyoo) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.1
Objective : To provide information about the accessory product of Broussonetia kazinoki Siebold or Broussonetia papyrifera (L.) Vent by analyzing old books of oriental medicine, domestic/international papers and related patents Methods : Old books related to the accessory product in the field of oriental medicine were reviewed, Research papers regarding the pharmacological activity of the by-products were reviewed and analyzed. Patents about the residual products were examined and classified by year and subject. Results: Seven kinds of by-products from Broussonetia kazinoki Siebold or Broussonetia papyrifera (L.) Vent has been used as medicines in oriental medicine. Recently, anti-oxidating, anti-cancer, anti-mutagenic and anti-inflammation activity of the residual product of these plants has been investigated through scientific research. There were 19 patents related with the accessory products of these plants, which were in the subjects of functional cosmetics, anti-inflammation, cleansing goods, hair restorers or improvement of learning ability, Further investigations about the activity of these plants are needed in bone metabolism, water balance and hemostasis in the future. Conclusion : Residual products from these plants is being used in various ways. However, more studies on the efficacy and mechanism, as well as safety, of these plants should be conducted precisely in the future.
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