http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국산 쌀보리 α - Amylase 저해물질의 분리 및 정제
문주석(Ju-Seok Moon),신창식(Chang-Shik Shin),최진상(Jine-Shang Choi),박석규(Seok-Kyu Park),심기환(Ki-Hwan Shim) 한국식품영양과학회 1995 한국식품영양과학회지 Vol.24 No.4
한국산 곡류 중의 α-amylase 저해물질의 이화학적 특성에 관한 기초자료를 얻기 위하여, 쌀보리로 부터 α-amylase 저해물질을 분리, 정제하여 다음과 같은 결과를 얻었다. 쌀보리 α-amylase 저해물질은 DEAE-cellulose, Concanavalin-A sepharose 및 FPLC superose 6 칼럼을 이용하여 분리ㆍ정제한 다음, SDS-PAGE 상에서 단일밴드를 확인하였고, capillary electrophoresis에서 순도를 확인하였으며, 정제된 저해물질의 비활성도는 336.7units/㎎, 정제도는 약 12배였으며, SDS-PAGE 상에서 분자량은 29KD였다. 쌀보리 α-amylase 저해물질의 주요 아미노산은 glutamic acid, aspartic acid 및 arginine 순으로 높았다. 정색반응 결과 쌀보리 α-amylase 저해물질은 당단백질로 추정되었으며, 탄수화물 함량은 1.0%로 나타났다. The α-amylase inhibitor from naked barley was purified by DEAE-cellulose, Concanavalin-A sepharose and superose 6 column chromatography, and confirmed by capillary electrophoresis. The purified a-amylase inhibitor showed a single band of 29KD in molecular weight when estimated by the SDS-PAGE. Its purity was increased by 12-fold as compared to its crude extract, and its specific activity was found to be 336.7units/㎎. The major amino acids of the α-amylase inhibitor from naked barley was appeared to be glutamic acid, aspartic acid and arginine. The inhibitor from naked barley was glycoproteins and carbohydrate content of inhibitor was 1.0%.
명승운(Seung Woon Myung),김동현(Dong Hyun Kim),김명수(Myung Soo Kim),강태경(Tae Kyeong Kang),민혜기(Hye Ki Min),장윤정(Yoon Jung Jang),손동렬(Dong Ryul Sohn),홍영훈(Young Hun Hong),신창식(Chang Shik Shin) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.3
The bioequivalence of two tiropramide products was evaluated in 18 health male volunteers following oral administration. Test product was Tiram^R tablet (Shin Poong SP-102) (Shin Poong Pharm. Co., Ltd.) and reference product was Tiropa^R tablet (Dae Woong Pharm. Co., Ltd.) One capsule of the test and reference product containing 100 mg of tropramide · hydrochloride was administered to the volunteers by randomized two period cross-over study (2 X 2 Latin square method). The drug concentration in plasma was determined by GC/MS for over a period of 12hours after administration. Analysis of variance reveal that there are no differences in AUC (area under the plasma concentration-time curve from time zero to infinity), Cmax (maximum plasma concentration) and Tmax (time to reach Cmax). The differences of mean AUC, Cmax and Tmax between two products were 3.85, 1.47 and -3.6%, respectively. Minimum detectable differences (%) at α=0.1 were all less than 20% given as a guideline (18.07, 17.00 and 20.69% for AUC, Cmax and Tmax, respectively) . From these results, the two products are bioequivalent.