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Burkholderia Pyrrocinia CAB08106-4의 국소자극성시험 및 피부감작성시험
이보승(Bo-Seung Lee),신성섭(Sung-Sup Shin),정창국(Chang-Kook Chung),백철기(Cheol-Ki Beak ),권민(Min Kwon),이범준(BeomJun Lee) 한국농약과학회 2019 농약과학회지 Vol.23 No.2
Burkholderia pyrrocinia CAB08106-4 has antibacterial efficacy against garlic black rot mycosis caused by Sclereotium cepivorum and Sclereotium sp. It is an environmentally friendly microbial product for the management and prevention of various plant pathogens including scarreotium cepivorum and Sclereotium sp. The purpose of this study is to evaluate Burkholderia pyrrocinia CAB08106-4 against local irritation and skin sensitization that develops in the skin and mucosa. In skin and eye irritation test, test substance was administered to the skin and eye of NewZealand White rabbits. Skin irritation test was performed for 72 hours and eye irritation test was performed for 7 days. Body weights were measured on days of before test substance administration, and on days 3 after administration in skin irritation test and measured on days of before test substance administration, and on days 3, 7 after administration in eye irritation test. As a result, general clinical signs, skin irritation, and eye irritation were not observed during the entire test period, and the body weight was increased normally. In the skin sensitization test, test substance was administered to the skin of Hartley guinea pigs, and skin was observed at 24 hours and 48 hours after the induction of the test substance. As a result, there were no general clinical signs due to administration of the test substance, normal weight gain was observed, no skin reaction such as erythema and edema was observed, and the sensitization index and the frequency index were calculated as 0 and 0%, respectively. From the above results, it was evaluated that the test substance did not cause skin irritation and eye irritation and did not cause any skin sensitization, so that it was not problematic.
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