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백작약 에탄올 추출물이 mouse embryonic fibroblast cells에 미치는 항산화 효과
윤희정 ( Hee Jung Yoon ),고은비 ( Eun Bi Go ),최민선 ( Min Sun Choi ),김동일 ( Dong Il Kim ),성정석 ( Jung Suk Sung ) 대한한방부인과학회 2012 大韓韓方婦人科學會誌 Vol.25 No.2
Objectives: Paeonia japonica has been widely used for gynecopathy and analgesic effects in Korean Traditional Medicine. The aim of the present study is to determine the antioxidant effect of Paeonia japonica extracts(PJE) by using mouse embryonic fibroblast cells(MEF cells). Methods: We evaluated Radical Scavenging Activity of PJE by the DPPH assay. Protective effect of the PJE on the hydrogen peroxide(H2O2) induced oxidative damage of MEF cells was analyzed by the MTT assay. The Morphological changes of MEF cells induced by P. japonica, H2O2 and P. japonica+H2O2 was evaluated by DAPI staining. And effect of PJE on the rate of apoptosis in MEF cells was measured using flow cytometry with Annexin V-FITC and PI double staining. Results: We observed that PJE contain significant DPPH radical scavenging activity. Cell viability of oxidative damaged cells treated with various concentrations of H2O2 was increased by treatment with PJE. Flow cytometric analysis of the cells treated with H2O2 in the absence or presence of PJE showed that the crumbled G1 peak was accumulated by the treatment with H2O2 alone, but restored by addition of PJE. Portion of cells that undergo apoptosis mediated by oxidative stress was decreased by treatment of PJE. The nuclear fragmentation occurred in the oxidative damaged MEF cells was also decreased by PJE treatment. Conclusions: Taken together, our results suggest that PJE exhibits significant antioxidant activity and functions to inhibit cell death mediated by oxidative damage induced apoptotic pathways.
성용길,오명식,김계용,성정석 동국대학교 생명과학연구소 1995 생명과학연구논문집 Vol.2 No.-
Biodegradable copoly(chitosan-g-N^ε-Carbobenzoxy-L-lysine) has been synthesized and characterized for biomedical applications. The physical and surface properties of the copolymer membranes were measured for tensible strength, elongation, and contact angles. The biodegradation of the polymer embranes by protease at 38°C was also measured and the proliferation of human fibroblast on the artificial skin was tested in vitro system.