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서용선(Yung Sun Suh),배진선(Jin Sun Bae) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6
N/A Backgrounds/Aims: Stomach cancer is the most common malignant tumor in Korea. The prognosis is much better in early cancer than in advanced state, and until now operation is the only measure that can potentially cure. We studied to know the factors influencing the survival rate after operation, which is very important to manage the patients. Methods: We analyzed 264 patients who underwent surgery for stomach cancer during three years between Janunaip 1988 and December 1990 at the Departrnent of Surgery, Chungnam National University Hospital, to know which may be important to influence the prognosis especially about age, sex, tumor size, location of tumor, gross form, invasion of primary tumor, histologic classification, TNM stage, lymph node metastasis, dissection of regional nodes, resection margin, and operation method. Results: There was a male preponderance with a male to female ratio of 2.2:1. The peak age of incidence was 7th(33.3%), followed by 6th(30.5%) and 5th(22.4%) decades. 5-year survival rates were as follows ; 66.9% in 30-59 years, 54.1% above 60 years; 58.7% for male, 65.7% for female; 82.0% below 2cm, 80.3% between 2 and 5cm, whi]e 45.4% above 5cm in diarneter; 50.0% for cardia, 63.3% for middle part, and 62.3% for antrum; 89.5% for early gastric cancer, 85.7% for Borrmann group I, 60.4% for Borrmann group II, 40.9% for Borrmann group III, 37.5% for Borrmann group IV; 91.7% for Tl, 88.0% for T2, 41.5% for T3, 16.7% for T4: 91.7% for well differentiated, 59.0% for moderately differentiated, 58.2% for poorly differentiated, and 37.5% for mucinous cancer; 89.6% for stage Ia, 87.0% for stage Ib, 85.7% for stage II, 36.5% for stage IIIa, 34.6% for stage IIIb, and 12.0% for stage IV; 84.3% for NO, 47.1% for Nl, 34.8% for N2, 20.0% for N3; 85.7% for D, 66.7% for D,, 26.3% for Dy29.6% for D, 57.4% for cancer-negative and 15.7% for cancer positive resection margin, and finally 60.2% for curative subtotal resection and 41.2% for curative total gastrectomy. Conclusions: The prognosis after operation for stomach cancer was influenced by several factors, I.e. it was more favorable in tumor size less than 2cm, early cancer, TO or Tl, and well differentiated cancer. There were little differences in 5-year survival rates between the tumor under 2cm and that of 2-Scm in diameter; between the locations; between Borrmann group III and IV; between Tl and T2 in lymph node state; between moderately and poorly differentiated; and between Ia, Ib and II, between IIIa and IIIb in TNM staging. After all, at present, radical operation in early state is most important to improve the result in managing the patients with stomach cancer.(Korean J Gastroenterol 1996;28:770-779)