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천왕보심단(天王補心丹)∘쌀발효추출물(GABAː gamma-aminobutyric acid 30%) 복합물의 抗스트레스에 대한 유효성 연구ː무작위 배정 및 이중맹검
홍초영 ( Choyoung Hong ),서상권 ( Seo Sang Gwon ),나승곤 ( Seunggon Na ),조호성 ( Hosong Cho ),이미경 ( Mi-kyung Lee ),진무현 ( Mu Hyun Jin ),노석선 ( Seok-seon Roh ),주영승 ( Youngsung Ju ) 대한본초학회 2023 大韓本草學會誌 Vol.38 No.2
Objectives : From this study, we sight to identify Anti-stress effect of Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA ː gamma-aminobutyric acid 30%) Complex Methods : In order to measure the degree of functional evaluation of tension relief due to stress, it was evaluated whether the psychological indicators VAS(Visual Analog Scale) and POMS(Profile Of Mood State) were improved. Which is generally used for stress measurement and has a high frequency of clinical use. All clinical trial subjects were required to take the drug once a day at 9 ± 30 min in the morning for 2 weeks. Results : After intake, the group that Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA ː gamma-aminobutyric acid 30%) Complex had a statistically significant improvement effect compared to before intake due to an improved 30.81% of the VAS scores. The POMS-T score improved 54.13%, the POMS-V score improved 117.5% and the POMS-F score improved 59%, which had a statistically significant effect compared to Placebo group (p<0.001). There is a significant difference between two group, so even considering the placebo effect, the anti stress effect was confirmed in the Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA ː gamma-aminobutyric acid 30%) Complex intake group. Conclusions : The above results showed that the Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA ː gamma-aminobutyric acid 30%) Complex had an anti-stress effect. Therefore, it is expected to be developed as a safe and comfortable mental care health functional food that can reduce the risk of drug abuse.
화장품용 W(마이크로바이오젤)/O/W 멀티-에멀젼 제조
정원욱(Won-Wook Jeong),서상권(Sang Gwon Seo),이의정(Eui Jung Lee),오주영(Joo-young Oh),이경진(Kyung Jin Lee) 한국고분자학회 2024 폴리머 Vol.48 No.1
Microbiogels made from natural polymers are attractive for biomedical applications such as drug delivery and have various manufacturing methods. However, it has drawbacks such as unstable yield and cumbersome separation process. This study presents a simple method to form cosmetic W (microbiogel)/O emulsion that produces microbiogel directly during cosmetic W/O emulsion manufacturing process and then stably produce the W (microbiogel)/O/W multi-emulsion through a continuous room temperature process. We confirmed that a partitioned structure was formed in which other particles exist within the particles dispersed in the outer water phase from microscopic observation of the prepared W/O/W multi-emulsion and the particle size and viscoelasticity of W/O emulsion and W/O/W multi-emulsion increased as the ratio of inner water phase (microbiogel) increased. This manufacturing method can produce high-content microbiogels and is of significant value in research on W/O/W cosmetic formulations that can encapsulate various water-soluble and oil-soluble active ingredients within a partitioned structure.