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한국인의 급성 및 만성 간질환에서 C 형 간염 바이러스 항체 ( anti - HCV ) 의 발현상
변관수(Kwan Soo Byun),서동진(Dong Jin Sah) 대한내과학회 1991 대한내과학회지 Vol.40 No.4
N/A Since the development of diagnostic tests for hepatitis A and B viruses in 1975, it was apparent that most cases of post-transfusion hepatitis are not caused by these agents or any other known hepatotropic virus such as cytomegalovirus or Epstein-Barr virus. Termed non-A, non-B hepatitis, the causative agent has remained frustratingly elusive despite intensive research for over a decade. However, a major causative agent of non-A, non-B hepatitis (hepatitis C virus) was characterized recently by using efficient nucleic acid extraction and cloning techniques coupled with an immunoscreening approach, and then a capture assay for circulating viral antibody (anti-HCV) to the recombinant-based antigen was developed. So we detected anti-HCV in the sera of 335 patients with various liver diseases using enzymelinked immunosorbent assay to evaluate the prevalence of anti-HCV in patients with acute and chronic liver diseases in Korea. In 69 patients with presumed acute non-A, non-B hepatitis, 9 cases (13.0%) were positive for anti-HCV, while 11 (30.6%) among 36 patients with HBsAg positive acute viral hepatitis, who had neither IgM anti-HAV nor IgM anti-HAV, were anti-HCV positive. Anti-HCV was detected in the sera of 13 (44. 8%) out of 29 patients with HBsAg negative chronic active hepatitis. In patients with HBsAg positive chronic active hepatitis, the positive rate of anti-HCV was significantly different (p<0.05) between those with HBeAg (13.3%) and without HBeAg (46.4%). The highest positive rate (50%) of anti-HCV was found in patients with HBsAg negative hepatocellular carcinoma, while 25% of patients with HBsAg negative liver cirrhosis were anti-HCV positive. These results suggest that hepatitis C virus has an important etiologic role in HBsAg negative chronic hepatitis and hepatocellular carcinoma in Korea, and superinfection of hepatitis C virus is not infrequent and may modify the natural course of chronic HBV infection.
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