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RISS 인기검색어
- 검색키워드
- 저자 : 백락주(Rak Joo Baek) (검색결과 4 건)
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우영대(Young Dae Woo),주용규(Yong Gyu Joo),백락주(Rak Joo Baek),이호왕(Ho Wang Lee) 대한바이러스학회 2000 Journal of Bacteriology and Virology Vol.30 No.1
Since Hantavax, formalin inactivated Hantaan virus vaccine (10,240 ELISA units/ml), has been developed in 1990 to prevent against haemorrhagic fever with renal syndrome (HFRS) caused by Hantaan or Seoul virus, it has been commercially available in Korea. Twenty-one healthy people were booster shot once and twice after prirnary basic vaccination with Hantavax. Seroconversion rates were measured by immunofluorescent antibody technique (IFAT), enzyme-linked immunosorbent assay (ELISA), high density composite particle agglutination (HDPA), and plaque reduction neutralization test (PRNT). Seroconversion rates of 21 vaccinees at one year after primary basic vaccination were 52.3%, 95.2%, 0.0%, 47.6%, and 28.6%, and 13 vaccinees at one month after 1st booster vaccination were 100%, 100%, 30.7%, 100% and 100% by IFAT, ELISA (IgG, IgM), HDPA and PRNT, respectively. Seroconversion rates declined slightly by twenty months, and they were 84.6%, 92.3%, 0.0%, 84.6% and 69.2% by IFAT, ELISA (IgG, IgM), HDPA and PRNT, respectively. Seroconversion rates of 9 vaccinees at three months after 2nd booster vaccination were 100%, 100%, 0.0%, 100%, and 88.9%, and 16 vaccinees at one year after the 2nd booster vaccination were 87.5%, 93.8%, 0.0%, 87.5% and 81.3% by IFAT, ELISA (IgG, IgM), HDPA and PRNT, respectively. Based on the above result Hantavax has proved a vigorous anamnestic response after the 1st and the 2nd booster vaccination and has persisted higher fluorescence, agglutination and neutralizing antibody titers in vaccinees.
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송기준(Ki Joon Song),강병철(Byung Chul Kang),이영은(Young Eun Lee),백락주(Rak Joo Baek),이용주(Yong Joo Lee),송진원(Jin Won Song) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.2
Reovirus was found to inhabit both the respiratory and the enteric tract of human and animals. The genome of reovirus comprises 10 segments of double-stranded RNA, total size 24 kbp. Nine strains of reovirus were isolated from human and field mice in Korea. Aseptically collected sera from human and lung tissues from field mice were used for virus isolation. For serotype determination, hemagglutination inhibition test was used, and three strains were confirmed to type 2 and six strains to type 3. To determine the genomic diversity and molecular phylogeny of reoviruses isolated in Korea, part of S4 genomic segment of reovirus was enzymatically amplified and directly sequenced. In nucleotide level, Apo98-35 strain showed 15.4%, 19.3%, and 14.4% differences compared to type 1 (T1L, Lang), type 2 (T2J), and type 3 reference strains, respectively. In amino acid level, Apo98-35 strain showed 10.5%, 13.7%, and 9.5% differences compared to type 1, type 2, and type 3 reference strains, respectively. Using the maximum parsimony method based on 285 bp spaning region of the S4 genomic segment, phylogenetic analysis indicated that Apo98-35 from Korea formed different phylogenetic branch. Our data obtained by sequence and phylogenetic analyses of reoviruses are consistent with the distinct geographically dependent evolution of reoviruses in Korea.
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우리나라에서 분리된 풍진바이러스의 염기서열 분석 및 유전자 발현
송진원(Jin Won Song),김태환(Tae Hwan Kim),김종헌(Jong Hun Kim),박광숙(Gwang Sook Park),이용주(Yong Joo Lee),백락주(Rak Joo Baek),송기준(Ki Joon Song) 대한바이러스학회 2000 Journal of Bacteriology and Virology Vol.30 No.1
During the recent epidemic period (1995-1996), seven strains of rubella virus were isolated in Korea. To analyze phylogenetic relationship between seven Korean strains and rubella virus strains from other different geographical areas, structural genes (El, E2 and C) of Korean strains were enzymatically amplified and automatically sequenced. The sequence similarities of the E1, E2 and C genes of the cosmopolitan types were 95.8 98.1%, 92.6 99.2% and 96.4-99.3% based on 1,441, 122 and 139 nucleotides and 96.9-98.5%, 90-100% and 97.8-100% based on 480, 40 and 46 amino acids compared to the sequences of strain RA27/3, respectively. In contrast, the sequence similarities of the E1, E2 and C genes of the Asian types were 91.5-92.1%, 83.6-88.5% and 91.4% based on nucleotides and 96.9-97.7%, 85.5% and 97.8% based on amino acids compared to the sequences of strain RA27/3, respectively. However, immunodominent epitopes of the E1 gene of the cosmopolitan and Asian types were well conserved, and the growth patterns in cell culture and immunofluorescent antibody titers in cross-reaction test showed no differences between two different types. In phylogenetic analysis based on nucleotide sequences of each gene regions, the cosmopolitan and Asian types formed two distinct phylogenetic lineages, These data showed two distinct genotypes of rubella viruses cocirculated in Korea, but no significant differences in the antigenicity of two different rubella virus strains were found.
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흰넓적다리붉은쥐 유래 한타바이러스 분리 및 분자생물학적 특성 비교
송기준(Ki Joon Song),윤형선(Hyung Sun Yoon),고은영(Eun Young Ko),정기모(Gee Mo Jung),박광숙(Gwang Sook Park),이용주(Yong Joo Lee),송진원(Jin Won Song),백락주(Rak Joo Baek) 대한바이러스학회 2000 Journal of Bacteriology and Virology Vol.30 No.1
Two distinct hantaviruses have been isolated from Apodemus agrarius in 1976 and Rattus norvegicus in 1980 in Korea. Since our serosurveys conducted in 1994, a genetically distinct hantavirus from Apodemus peninsulae has been investigated. To isolate hantavirus from A. peninsulae captured in Korea, the lung homogenate of seropositive A. peninsulae inoculated Vero E6 cells. Viral antigen was detected in a progressively higher percentage of cells with subsequent passage after 80 days postinoculation. The new isolate from seropositive Apodemus peninsulae was designated Suchong virus after Suchong valley located in northeastern region of South Korea. Comparing with hantaan virus 76-118 strain, Suchong virus-1, 2, 3 and 4 showed the similarity of 71.0-91.8% at nucleotide and 90.9-94.8% at amino acid sequences in 231 nucleotides region of M segment, and the similarity of 75.1-81.0% at nucleotide and 97.5-100% at amino acid sequences in 237 nucleotides of S segment.
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