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스핑고신 키나아제 1 저해제인 PF-543과 PF-543 유사체 (22c)의 항암활성
백동재(Dong Jae Baek),박은영(Eun Young Park) 대한약학회 2018 약학회지 Vol.62 No.5
PF-543 selectively inhibits sphingosine kinase (SK)1 most potently among the known SK inhibitors. Although SK1 inhibitors have been reported to have anticancer effect, PF-543 has lower anticancer activity in some cancer cells compared with selective inhibition of SK1. Recent PF-543 derivatives were synthesized in Pfizer and observed inhibitory effects on SK1, suggesting that (S)-1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-3-ol (22c) is more effective than PF-543. We investigated whether 22c improved the anticancer activity compared to PF-543 in proportion to the SK-1 inhibitory effect. The cytotoxic effect of PF-543, 22c and 5-fluorouracil was compared in HT29, HCT116 and AGS cells. PF-543 showed slightly higher cytotoxic effect than 22c in all cells. These results suggest that the SK inhibitory activity and the anticancer effect of the SK inhibitor are not necessarily proportional to each other. Therefore, development of SK inhibitor as an anticancer agent requires comparison of anticancer activity.
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정유림(Yu Rim Jeong),박은영(Eun-Young Park),백동재(Dong Jae Baek),방준석(Joon Seok Bang),김광준(Kwang Joon Kim) 대한약학회 2023 약학회지 Vol.67 No.5
Digital therapeutics (DTx) are defined as high-quality software designed to prevent, manage, and treat medical disorders or diseases by providing evidence-based therapeutic interventions. In this study, an investigation was conducted to examine the characteristics of DTx, including their methods, safety-related data, and user evaluations of reSET®, reSET-O®, and Somryst®. These DTx solutions have recently obtained the first FDA approval and the first insurance code registration by government. However, there are limitations in terms of the quantitative scale of patient feedback evaluations and concerns about accuracy, as indicated by research findings. Nevertheless, with the active global development of DTx and the increasing scale of investment, pharmacists need to pay attention to and prepare for this innovative treatment concept.
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