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만성 신부전 환자에서 99mTc - HMDP 골신티그램상 섭취정도와 혈중 osteocalcin , 부갑상선 호르몬치와의 상관관계
김춘열(Choon Yul Kim),정수교(Soo Kyo Chung),신경섭(Kyung Sub Shinn),손형선(Hyung Sun Sohn),김의녕(Euy Neyng Kim),방찬영(Chan Young Band),박철휘(Chul Whee Park),장윤식(Yoon Sik Chang) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3
N/A In this preliminary study, plasma osteocalcin, PTH level and Tc-99m-HMDP (hydro- xymetylene diphosphonate) bone uptake(BU) were measured in 14 patients with chronic end-stage renal failure who were on maintenance hemodialysis. The aim of this study was to determine the difference of bone uptake between renal failure patients and normal volunteers, and to determine the correlation between bone uptake and osteocalcin a sensitive and specific marker of osteoblastic activity and PTH - a important hormone of bone metabolism. There was a statistically significant increase in 180 minute uptake in the patient group when compared to the normal volunteers while there was no statistically significant difference in 20 minute uptake. Plasma osteocalcin and PTH levels were also significantly elevated compared to normal values. But the correlation between osteocalcin, PTH and 20 and 180 minute bone uptake was not significant. In conclusion, our preliminary study suggests that, in chronic renal failure patients, 180 minute Tc-99m-HMDP bone uptake is increased significantly without direct correlation with serum osteocalcin or PTH levels. It seems that further study is needed to evaluate other unknown factors that may influence the direct correlation between bone uptake and plasma osteocalcin and PTH in patients with chronic renal failure.