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Felty 증후군 환자에서 종양궤사인자 억제제 사용 중 발생한 보웬병
박하열 ( Ha Yeol Park ),김현숙 ( Hyun Sook Kim ),홍란 ( Ran Hong ) 대한내과학회 2012 대한내과학회지 Vol.83 No.3
Felty`s syndrome is an uncommon condition characterized by the combination of rheumatoid arthritis (RA), splenomegaly, and neutropenia. Disease-modifying anti-rheumatic drugs and biologic agents have been used to treat early RA to achieve remission. Anti-tumor necrosis factor (TNF)-A agents are effective for controlling the disease; however, some studies have suggested the possibility of adverse effects such as increased frequency of infection or malignancy. Bowen`s disease, known as squamous cell carcinoma in situ, is a skin cancer that can be caused by sun exposure, arsenic ingestion, human papilloma virus, skin damage, and prolonged immunosuppression. We report the case of a 64-year-old female diagnosed with Bowen`s disease during treatment with an anti-TNF agent for Felty`s syndrome with a review of the literature.
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박하열 ( Ha Yeol Park ),신병철 ( Byung Chul Shin ) 대한내과학회 2020 대한내과학회지 Vol.95 No.4
Kidney transplantation is the treatment of choice for end-stage renal disease. A successful kidney transplant improves the quality of life and reduces the mortality risk of patients, as compared to maintenance dialysis. The number of patients awaiting kidney transplantation has steadily increased, and the gap between allograft supply and demand continues to widen despite initiatives to expand the use of nonstandard deceased-donor allografts. The use of organs from living donors is one strategy to address the need for transplants. A medical, surgical, and psychosocial evaluation is mandatory prior to living kidney donation to ensure that the donor candidate is in good health and has normal kidney function, is not a risk to the recipient with respect to transmission of infections and malignancy, and will not face unacceptable risks after donation. (Korean J Med 2020;95:260-265)
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