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박주형(Joohyung Park),김웅(Woong Kim),김우창(Woochang Kim),김민우(Minwoo Kim),김치현(Chihyun Kim),박현준(Hyunjun Park),이원석(Wonseok Lee),박진성(Jinsung Park) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
In this study, we developed a novel sandwich-type electrochemical aptasensor to detect 25-hydroxy vitamin D3 (25OHVD3). 25OHVD3 is an important biomarker of various disorders such as obesity, digestive problems, osteoporosis, and mental illness, even coronavirus disease 2019. We fabricated heterogeneous nanostructures consisted of molybdenum disulfide and electrochemically reduced graphene oxide composite for amplification of the electrochemical signal. To enhance the sensing performance applying the sandwich-type strategy, methylene blue labeled 1,2,4-triazole-3,5-dione (MB-TAD) was functionalized on an electrochemical aptasensor. Wherein, MB as redox mediators in the electrochemical aptasensor is responsible for electron production and TAD can combine with 25OHVD3 forming an aptamer/25OHVD3/MB-TAD complexes. The binding events of 25OHVD3 were studied by monitoring differential pulse voltammetry signals, and the electrochemical aptasensor exhibited a highly sensitive response. The detection capability of the electrochemical aptasensor showed a linear detection range from 0.1 to 150 ng/mL, with a limit of detection of 0.02 ng/mL. The electrochemical aptasensor selectively detected 25OHVD3 from other vitamins and it offered the possibility of detection of 25OHVD3 in the saliva. Our results suggested that the electrochemical aptasensor based on the sandwich-type method is a highly selective and ultrasensitive method with great potential for quantitative detection of vitamins in saliva.