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RISS 인기검색어
- 검색키워드
- 저자 : 박제우(JW Park) (검색결과 2 건)
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난소홀몬이 가토 Insulin 131I 대사에 미치는 영향
박제우(JW Park) 대한산부인과학회 1966 Obstetrics & Gynecology Science Vol.9 No.11
Twenty one of ovariectomized rabbits were divided into 3 groups: the first group for control, the second group for estrogen stimulated group and the third group for progesterone stimulated group. In each group, after a single injection of insulin-131I(30-100μc.), blood samples were withdrawn at the interval of 10 minutes for 50 minutes and plasma disappearance of injected insulin-131I with time were observe. On the other hand, 50 minutes after injection of insulin-131I of plasma-time curves, turnover rates of insulin and half time, which is the time required to turnover a half insulin pool, were valulated from each group. On the other hand, 50 minutes after injection of insulin-131I, animals were sacrificed and various tissues were excised. Weighed tissues were mixed with 10% trichloroacetic acid(TCA) in motor and divided into 2 fractions by centrifugation. Each fraction of tissue homogenate was counted for radioactivity by means of well type scintillation counter. Insulin-131I spaces in various tissues were calculated by obtaining the ratio of radioactivities of TCA precipitable fractions of tissues to that of plasma, while 131I compound space, which is the distribution spaces of degradated products of injected insulin-131I, were calculated with ratios of radioactivities of TCA soluble fraction of tissues to that of plasma. Alterations in turnover rates of insulin by ovarian hormons were analyzed by connection the distribution spaces of insulin-131I in various tissues of each group. 1) After a single injection of insulin-131I, plasma disappearance of insulin-131I was decreased exponentially with time showing straight line on the semilogarithmic paper. Therefore, turnover rate can be calculated by obtaining the slope of radioactivities of plasma insulin-131I vs. time curve and also half time(t½)of insulin turnover by the first order kinetic equation. The turnover rate of insulin was mean of 1.90%/min. in the first group, 2.53%/min. in the secon group and 2.18%/min. in the third group. These data showed that turnover rates of insulin were increased by stimulation with ovarian gormones. 2) Insulin-131I space in the kidney tisseue showed most highest value and averaged about 700%, which value represents about 7 times of concentration of plasma insulin-131I in the kidney. In the other tissues insulin-131I space were decreased by in order of spleen, skin, heart, liver, small intestine, uterus, adipose, skeletal muscle and brain tissues. However, there were little differences in insulin-131I space between control and ovarian hormone stimulated groups. 3) In order to observe the degradation of insulin in various tissues, 131I compound spaces were determined by ratio between radioactivities of TCA soluble fractions of tissues and plasma. 131I compound spaces in kidney, liver, spleen and adipose tissues showed more than 100%, in which tissues radioactivities of TCA soluble fractions were more concentrated than in the plasma. It seems that these tissues would be principal sites of insulin degradation. In the other tissues, 131I compound spaces were decreased by in order of small intestine, heart, skin, uterus, skeletal muscle and brain tissues. However, there are remarkable increase in the 131I compound spaces of kidney and liver which have insulinase system by stimulation of ovarian hormones and also degradation of
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면역전기영동법에 의한 자궁경관점액중의 혈청단백에 대하여
박제우(JW Park),권영조(YJ Kwon),임수덕(SD Lim) 대한산부인과학회 1966 Obstetrics & Gynecology Science Vol.9 No.11
In recent years the analysis of the protein components in the cervical mucus has drawn more attention with respect to the possible occurrence of a biologic infertility cause by an immune reaction between sperm antigen and cervical mucus antibodies, and antimicrobial prophyractic immunity. Immunoelectrophoretic studies on cervical mucus have already been undertaken by several workers, but there is not complete agreement as regards to proteins in cervical scretions obtained from nonpregnant women as yet probable due to differences in techniques used. It was the purpose of this study to investigate in single, undiluted specimens the appearance of serum proteins in cervical mucus of Korean women during different stages of the menstrual cycle. Summary 1) A complete study of the proteins of normal cervical mucus has been made by immunoelectrophoresis in cases of Korean women. 2) Albumin, transferrin, and gamma globulin(IgG) were always found, and in the half of the cases alpha-2 globulin and IgA were present. 3) No significant differences in protein component of cervical mucus were found in regard to menstrual cycle. 4) The possible role of cervical mucus(especially, IgG and IgA) in the production of biological infertility and antimicrobial prophylactic immunity was discrssed together with the limits and merits of the immuno elctrophoretic method in the study of the cervical mucus.
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