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오디 추출물(Morus alba L.)의 혈행개선 효과
박연실(Youn-Sil Park),강성선(Seong-Sun Kang),최형자(Hyoung-Ja Choi),양성준(Sung-Jun Yang),손호형(Ho-Hyeong Shon),서형호(Hyeong-Ho Seo),정종문(Jong-Moon Jeong) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.4
본 연구에서는 다양한 생리활성물질을 다량 함유하고 있는 국내산(전라북도 부안군) 오디의 혈액순환장애의 개선 효과를 확인하기 위하여 in vitro 및 고지혈증 동물모델을 이용한 실험을 진행하였다. MBE가 DPPH 라디칼을 50% 소거하는 SC50값은 89.36±5.46 μg/mL로 정제되지 않은 복합물질임을 감안하면 다른 식물추출물에 비해 항산화능이 우수함을 알 수 있었다. RAW 264.7 세포 및 HepG2 세포에 대한 MBE의 세포독성은 2,500 μg/mL 이하의 농도를 처리한 경우 세포독성을 나타내지 않았다. In vitro 실험에서 COX-2의 활성저해 효과를 측정한 결과 MBE의 IC50값은 215.94±18.15이었고, human LDL의 산화억제 효과는 최종반응 농도가 200 및 400 μg/mL일 경우 유의적인 감소(P<0.05)효과가 있었다. 또한 TNF-α에 의하여 활성화된 HUVECs에서 MBE가 증가된 ICAM-1 및 VCAM-1의 발현을 감소(P<0.05)시켰으며 LPS에 의하여 활성화된 RAW 264.7 세포에서 MBE가 증가된 COX-2 및 5-LO의 발현을 감소(P<0.05)시킴을 알 수 있었다. 고지혈증 동물모델을 이용한 실험에서 MBE의 일부 실험군(200 mg 및 400 mg/kg 체중/day, 14 days)에서 혈청 total cholesterol의 수치는 음성대조군에 비해 유의적으로 감소(P<0.05)시켰으나 혈청C-reactive protein의 수치는 모든 실험군에서 음성대조군 대비 유의적으로 감소하지 않았다. 이러한 MBE의 항산화능, COX-2 활성억제 및 COX-2와 5-LO의 발현억제를 통한 염증억제, 혈중 total cholesterol 감소를 통한 이상지질혈증의 개선 효과 및 ICAM-1과 VCAM-1의 발현억제를 통한 혈관협착 방지의 효과들을 종합해 보면 오디추출물인 MBE가 혈액순환장애를 유발하거나 확대시키는 다양한 핵심요소들을 다각도로 개선시킴으로써 혈액순환장애의 예방과 치료에 긍정적인 효과가 있을 것으로 사료된다. The objective of this study was to investigate the beneficial effects of mulberry extract (MBE) on blood flow improvement. The SC50 value for the DPPH radical scavenging activity of MBE was 89.36±5.46 μg/mL. Analysis of the cellular toxicity of MBE on RAW 264.7 and HepG2 cells showed no toxicity under a concentration of 2,500 μg/mL. We found that MBE inhibited the enzyme activity of cyclooxygenase (COX)-2 as well as oxidation of human LDL. Western blotting analysis showed that MBE inhibited protein expression of COX-2 and 5-lipoxygenase in RAW 264.7 cells. In addition, MBE inhibited protein expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in human umbilical vein endothelial cells. Furthermore, MBE reduced the serum levels of total cholesterol and C-reactive protein in a concentration-dependent manner. These results both in vitro and in vivo suggest that MBE can be employed for the improvement of blood flow.
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박보현 ( Bo Hyun Park ),이태진 ( Tae Jin Lee ),박연서 ( Youn Seo Park ),김윤미 ( Yun Mi Kim ) 한국보건경제정책학회 2015 보건경제와 정책연구 Vol.21 No.4
To identify the relationship between the competitive intensity of the market and CS rates to help understanding the affecting factors on CS rates in hospitals. The data was extracted from delivery claims which were submitted to Health Insurance Review & Assessment Service by hospitals. A total of 419,547 mothers who delivered at 1,077 hospitals in 2006 were selected. Statistical regression techniques were used to identify the associations between intensity of competition and CS rates. The competitive intensity of general hospitals (HHI: 3,901) showed lower than medium-small hospitals (HHI: 4,255). In case of pooling model, the higher the competitive intensity of hospitals in the Korean delivery service market is, the higher the CS rate (OR for HHI 0.893, 95%CI 0.808-0.906). This result was identical in separate model. The competitive intensity between hospitals is determined to be one of the important nonclinical factors that affect the CS rates of healthcare hospitals.
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1990년대 중반 이후 병상 공급 및 환자들의 병원이용 양상 변화에 관한 분석
박형근 ( Hyeung Keun Park ),박연서 ( Youn Seo Park ) 한국보건경제정책학회 2011 보건경제와 정책연구 Vol.17 No.1
The aim of this study is to evaluate the trends of acute hospital beds supply and acute hospital utilization after deregulation of hospital beds in 1990s. This study calculate hospital bed proportions and hospital market shares by hospital characteristics, each hospital`s market shares and turnover rates for 1996-2005 using ``Patient Survey Data`` which has been gathered by the Ministry of Health and Welfare every three years. The concentration of patients into Seoul is examined, too. The results show the constant increase of acute hospital beds by ``hospitals``, hospital bed expansion of general hospitals and decrease of hospital bed proportions where has been in Seoul in the bed supply side. In the hospital utilization side, it appear that total ``hospitals`` market share has been continuously increased but less than it`s growth of bed composition, small-scale general hospital market share has been decreased and the market share of big4 hospitals in Seoul. It is confirmed that the growth rate of patients that turn to hospitals in Seoul to get best outcomes has been faster than on the average rate.
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