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김철근,박종군,박상대,Kim, Chul-Geun,Park, Jong-Kun,Park, Sang-Dai 생화학분자생물학회 1983 한국생화학회지 Vol.16 No.2
CHO 세포에 있어서 강력한 poly(ADP-ribose) polymerase 저해제인 benzamide와 3-aminobenzmide는 MMS와 MNNG에 의한 DNA 단사절단을 증가시켰으며 단사절단의 재결합을 유의성 있게 억제하였다. 이들 저해제는 또한 MNNG에 의한 비주기성 DNA 합성(UDS)과 자매염색분체 교환(SCE)에 상승 효과를 나타내었다. MMS와 MNNG의 복합처리에 의한 UDS와 단사절단은 상가효과를 보이나 저해제 처리에 의해 이의 효과는 상승되었다. 이들 결과로 보아 poly(ADP-ribose)는 DNA에 단사절단이 일어날때마다 염색사구초를 안정화 시킴으로서 DNA 손상에 대한 회복에 조절작용을 나타낸다고 사료된다. Benzamide and 3-aminobenzamide, potent inhibitors of poly (ADP-ribose) polymerase, increased MMS or MNNG-induced DNA strand breaks and significantly retarded the rejoining of strand breaks in CHO cells. These inhibitors also synergistically enhanced the frequencies of unscheduled DNA synthesis (UDS) and sister chromatid exchanges (SCE) induced by MNNG. Amounts of UDS and strand breaks induced by the combined treatment with MMS and MNNG were found to be additive but these amount were enhanced in the presence of inhibitors. These results suggest that poly (ADP-ribose) functions a regulatory role in the repair of DNA damage by virtue of stabilizing chromatin structure whenever strand breaks occur in DNA.
알킬화제에 의한 DNA 단사절단 , 절제회복 및 자매염색분체 교환에 미치는 Poly ( ADP - ribose ) polymerase 저해제의 상승효과
김철근,박종군,박상대 ( Chul Geun Kim,Jong Kun Park,Sang Dai Park ) 생화학분자생물학회 1983 BMB Reports Vol.16 No.2
Benzamide and 3-aminobenzamide, potent inhibitors of poly (ADP-ribose) polymerase, increased MMS or MNNG-induced DNA strand breaks and significantly retarded the rejoining of strand breaks in CHO cells. These inhibitors also synergistically enhanced the frequencies of unscheduled DNA synthesis (UDS) and sister chromatid exchanges (SCE) induced by MNNG. Amounts of UDS and strand breaks induced by the combined treatment with MMS and MNNG were found to be additive but these amount were enhanced in the presence of inhibitors. These results suggest that poly (ADP-ribose) functions a regulatory role in the repair of DNA damage by virtue of stabilizing chromatin structure whenever strand breaks occur in DNA.