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- 저자 : 박건혁 ( Gun Hyuk Park ) (검색결과 2 건)
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MPTP로 유도된 Parkinson`s disease 동물 모델에서 항염증효과를 통한 측백엽의 도파민신경보호 효과
박건혁 ( Gun Hyuk Park ),김효근 ( Hyo Geun Kim ),주미선 ( Mi Sun Ju ),김애정 ( Ae Jung Kim ),오명숙 ( Myung Sook Oh ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.3
Objectives : The aim of this study was to investigate the protective effect of extract of Thuja orientalis leaves (TOFE) against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity by inhibition of inflammation in in vitro and in vivo models of Parkinson`s disease (PD). Methods : We evaluated the effect of TOFE against lipopolysaccharide (LPS)/1-methyl-4-phenylpyridinium (MPP+) toxicity using nitric oxide (NO) assay, inducible NO synthase and cyclooxygenase 2 western blot, tyrosine hydroxylase and microglia activation immunohistochemistry (IHC) in BV2 cell, primary rat mesencephalic neurons, or C57BL/6 mice. We also evaluated the effect of TOFE in mice PD model induced by MPTP. C57BL/6 mice were treated with TOFE 50 mg/kg for 5 days and were injected intraperitoneally with four administrations of MPTP on the last day. We conducted behavioral tests and IHC analysis to see how TOFE affect MPTP-induced neuronal loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) and striatum (ST) of mice. To assess the anti-inflammation effects, we carried out glial fibrillary acidic protein and macrophage-1 antigen integrin alpha M in IHC in SNpc and ST of mice. Results : In an in vitro system, TOFE decreasesd NO generations in BV2 cells. TOFE protected dopaminergic cells against LPS or MPP+-induced toxicity in primary mesencephalic dopaminergic neurons. In vivo system, TOFE at 50 mg/kg treated group showed improved motor deteriorations than the MPTP only treated group and TOFE significantly protected striatal dopaminergic damage from MPTP-induced neurotoxicity in mice. Moreover, TOFE inhibited activation of astrocyte and microglia in SNpc and ST of the mice. Conclusions : We concluded that TOFE showed anti-parkinsonian effect by protection of dopaminergic neurons against MPTP toxicity through anti-inflammatory actions.
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현지초(玄之草)의 진통(鎭痛) 및 항염증(抗炎症) 효과
오명숙 ( Myung Sook Oh ),주미선 ( Mi Sun Ju ),정현욱 ( Hyun Uk Jeong ),김효근 ( Hyo Geun Kim ),박건혁 ( Gun Hyuk Park ),윤유석 ( You Suk Youn ),김영옥 ( Young Ock Kim ),김선여 ( Sun Yeou Kim ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.3
Objectives: The present study investigated the anti-nociceptive and anti-inflammatory properties of the water extract of Geranii Herba (The stem and leaves of Geranium thunbergii Sieb. et Zucc.) in the animal models of pain and inflammation. Methods: We evaluated the anti-nociceptive and anti-inflammatory activities of Geranii Herba extract (GHE) using the writhing test, tail-flick test, carrageenan-induced paw edema and xylene-induced ear edema models. Two dose of GHE (100 and 1000mg/kg) was administrated orally to the mice. Control group received normal saline and ibuprofen (50mg/kg) was used as a positive control drug. Results: GHE 1000mg/kg treated group showed an increased tail-flick response time in the tail-flick test and inhibitory effect on writhing syndrome induced by acetic acid. Treatment with GHE at the same dose inhibited ear edema induced by xylene and foot edema induced by carrageenan toxicity. Conclusion: The results demonstrate that GHE has anti-nociceptive and anti-inflammatory effects in the various models of nociception and inflammation.
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