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구제요법으로 시행한 소라페닙 치료에 극적인 반응을 보인 폐전이를 동반한 진행성 간세포암종 1예
김대하 ( Dae-ha Kim ),민지호 ( Gee Ho Min ),이동원 ( Dong-won Lee ),안계련 ( Ke Ryun Ahn ),김지혜 ( Ji Hye Kim ),서상준 ( Sang-jun Suh ),정영걸 ( Young Kul Jung ),임형준 ( Hyung Joon Yim ) 대한간암학회 2016 대한간암학회지 Vol.16 No.1
Sorafenib is a multi-targeted tyrosine kinase inhibitor that inhibits Raf kinase and the vascular endothelial growth factor receptor intracellular kinase pathway and is the first agent to demonstrate a statistically significant improvement in overall survival for patients with advanced hepatocellular carcinoma (HCC). However, there were few cases of partial or complete response reported in the previous studies. We herein report a case of dramatic partial response in a patient who had advanced HCC with multiple lung metastasis and portal vein thrombosis treated with sorafenib. (J Liver Cancer 2016;16:57-62)