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연구논문 : 의약화학 ; 2,4,6-치환 피리딘 유도체의 합성, topoisomerase 1 억제능 및 구조-활성 관계 연구
조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장영동 ( Yurng Dong Jahng ),박재규 ( Jae Gyu Park ),정태천 ( Tae Cheon Jeong ),조원제 ( Won Jea Cho ),최상운 ( Sang Un Choi ) 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
연구논문 : 의약화학 ; COX 및 5-LOX에 대한 이중 억제 활성을 갖는 프로페논 모핵의 간단한 방향족 화합물의 합성
장영동 ( Yurng Dong Jahng ),조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장현욱 ( Hyeun Wook Chang ),주혜경 ( Hye Kyung Ju ),정태천 ( Tae Cheon Jeong ),이응석 ( Eung Seok 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
Synthesis, Characterization and in Vitro Identification of N^7-Guanine Adduct of 2-Bromopropane
Zhao, Long-Xuan,Kim, Eun-Kyung,Lim, Hyun-Tae,Moon, Yoon-Soo,Kim, Nam-Hee,Kim, Tae-Hyung,Choi, Heesung,Chae, Whigun,Jeong, Tae Cheon,Lee, Eung-Seok 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Recently, we have reported that 2-bromopropane might have an immunotoxic potential in rats when exposed for 28 days. In the present studies, the possibility of 2i-deoxyguanosine adduct formation by 2-bromopropane was investigated in vitro to elucidate molecular mechanism of 2-bromopropane-induced immunosuppression. N^7-Guanine adduct of 2'-bromopropane (i.e., N^7-isopropyl guanine) was chemically synthesized and structurally characlerized by analysis of UV, ^H-NMR, ^12C-NMR, COSY and fast atom bombardment, mass spectrometry to use as a reference material. Incubation of 2'-deoxyguanosine with an excess amount of 2-bromopropane in PBS buffer solution, pH 7.4, AT 37℃ for 16 h, followed by a thermal hydrolysis, produced a detectable amount of N^7-isopropyl guanine by an HPLC and UV analysis. The present results suggest that 2-bromopropane might form a DNA adduct in N^7 position of 2'-deoxyguanosine at a physiological condition.